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科研机构
上海药物研究所 [9]
西北高原生物研究所 [2]
力学研究所 [1]
合肥物质科学研究院 [1]
内容类型
期刊论文 [13]
发表日期
2021 [13]
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Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGF beta signaling
期刊论文
ONCOGENE, 2021, 页码: 10
作者:
Kong, Ya
;
Zhang, Yutian
;
Wang, Hanlin
;
Kan, Weijuan
;
Guo, Haoran
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2022/01/04
Ketogenesis impact on liver metabolism revealed by proteomics of lysine beta-hydroxybutyrylation
期刊论文
CELL REPORTS, 2021, 卷号: 36, 期号: 5, 页码: 17
作者:
Koronowski, Kevin B.
;
Greco, Carolina M.
;
Huang, He
;
Kim, Jin-Kwang
;
Fribourgh, Jennifer L.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
Edible Bird's Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte
期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12, 页码: 18
作者:
Lai QWS
;
Guo MSS
;
Wu KQY
;
Liao ZT
;
Guan DS(关东石)
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2022/01/12
edible bird's nest
sialic acid
moisturizing
filaggrin
filaggrin-2
atomic force microscopy
METTL3-induced UCK2 m(6)A hypermethylation promotes melanoma cancer cell metastasis via the WNT/beta-catenin pathway
期刊论文
ANNALS OF TRANSLATIONAL MEDICINE, 2021
作者:
Wu, Hao
;
Xu, Haochao
;
Jia, Dongdong
;
Li, Tao
;
Xia, Liming
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/08/30
Uridine-cytidine kinase 2 (UCK2)
database
m(6)A
metastasis
melanoma cancer
A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2021, 卷号: 120, 页码: 12
作者:
Huang, Suling
;
Wu, Yanwei
;
Zhao, Zhuohui
;
Wu, Bing
;
Sun, Kai
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2021/08/17
Macrophage
NLRP3 inflammasome
Hepatic lipid accumulation
NASH
FXR
Role of CD8(+) T lymphocyte cells: Interplay with stromal cells in tumor microenvironment
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 6, 页码: 1365-1378
作者:
Xie, Qin
;
Ding, Jian
;
Chen, Yi
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/08/17
CD8(+) T lymphocyte
Stromal cell
Tumor microenvironment
Immunosuppression
Immunotherapy
Antitumor
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
期刊论文
CELL METABOLISM, 2021, 卷号: 33, 期号: 6, 页码: 1221-+
作者:
Liu, Yi
;
Liang, Guanghao
;
Xu, Hongjiao
;
Dong, Wenxin
;
Dong, Ze
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/08/17
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Li, Wen
;
Liao, Li-ping
;
Song, Ning
;
Liu, Yan-jun
;
Ding, Yi-luan
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/06/11
glyceraldehyde 3-phosphate dehydrogenase
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose
hydrogen deuterium exchange mass spectrometry
reversible inhibitor
glycolysis
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