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浏览/检索结果: 共116条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6 作者:  Yang, Xiangbo;  Lu, Huimin;  Xie, Hang;  Zhang, Binbin;  Nie, Tianqing 收藏  |  浏览/下载：25/0  |  提交时间：2022/01/18 Binding studies  Drug discovery  Necroptosis  RIPK1 inhibitors  Sepsis   A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11 作者:  Cheng, Zhiyang;  Huang, Ying;  Shen, Qianqian;  Zhao, Yangrong;  Wang, Lei 收藏  |  浏览/下载：86/0  |  提交时间：2021/11/04 Cancer  beta-glucuronidase  Bioconjugation  Albumin  Camptothecin   Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine 期刊论文 LIFE SCIENCES, 2021, 卷号: 287, 页码: 14 作者:  Xue, Yaru;  Ren, Xuelian;  Zhu, Zhengdan;  Lei, Peng;  Liu, Mengling 收藏  |  浏览/下载：39/0  |  提交时间：2022/01/18 3-n-butylphthalide  Hepatotoxicity  Oxidative stresses  Covalent protein modification  Drug-drug interaction   STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12 作者:  Wu, Bing;  Xu, Meng-meng;  Fan, Chen;  Feng, Chun-lan;  Lu, Qiu-kai 收藏  |  浏览/下载：59/0  |  提交时间：2022/01/18 acute lung injury  STING  vascular endothelial cells  inflammatory cytokines  chemokines  chemotaxis   A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies 期刊论文 JOURNAL OF IMMUNOLOGICAL METHODS, 2021, 卷号: 499, 页码: 6 作者:  Song, Yakai;  Deng, Xiaojie;  Shi, Wei;  Tang, Feng;  Huang, Wei 收藏  |  浏览/下载：19/0  |  提交时间：2022/01/04 FcRn  TR-FRET  mAb  ADC  Pharmacokinetics   Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Dong, Ying;  Tang, Bi-xi;  Wang, Qi;  Zhou, Li-wei;  Li, Cong 收藏  |  浏览/下载：73/0  |  提交时间：2022/01/04 idiopathic pulmonary fibrosis  DDRs  kinase inhibitor  indazole derivatives  XBLJ-13  nintedanib  bleomycin-induced pulmonary fibrosismouse model   Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site 期刊论文 ACS CHEMICAL BIOLOGY, 2021, 卷号: 16, 期号: 11, 页码: 2444-2452 作者:  Wang, Jiang;  Yang, Dehua;  Cheng, Xi;  Yang, Linlin;  Wang, Zhaohui 收藏  |  浏览/下载：27/0  |  提交时间：2022/01/04 Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity 期刊论文 ISCIENCE, 2021, 卷号: 24, 期号: 11, 页码: 22 作者:  Hu, Lin;  Chen, Fuxian;  Wu, Chao;  Wang, Jun;  Chen, Si-si 收藏  |  浏览/下载：38/0  |  提交时间：2022/01/18 Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13 作者:  Chen, Cheng;  Ren, Yong-mei;  Zhu, Jian-zhong;  Chen, Jia-li;  Feng, Zhe-ling 收藏  |  浏览/下载：56/0  |  提交时间：2022/01/04 Ainsliadimer C  interleukin-1 beta  macrophages  NLRP3 inflammasome  Sirtuin 1  adipose tissue inflammation  obesity  metabolic disorders  EX-527  dexamethasone   Discrete genetic loci in human gutBacteroides thetaiotaomicron confer pectin metabolism 期刊论文 CARBOHYDRATE POLYMERS, 2021, 卷号: 272, 页码: 13 作者:  Li, Meixia;  Li, Saijuan;  Guo, Xiaozhen;  Guo, Ciliang;  Wang, Yeqin 收藏  |  浏览/下载：62/0  |  提交时间：2021/11/04 Polysaccharide  Pectin  Human gut microbiota  Metabolism  Bacteroides