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浏览/检索结果: 共12条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586 作者:  Shan, Hui;  Yao, Sheng;  Ye, Yang;  Yu, Qiang 收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01 JAK/STAT  3-deoxy-2 beta,16-dihydroxynagilactone E  tyrosine kinase inhibitor  allosteric inhibitor  cancer   Simultaneous determination of alflutinib and its active metabolite in human plasma using liquid chromatography-tandem mass spectrometry 期刊论文 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 176, 页码: 6 作者:  Liu, Xiaoyun;  Li, Wei;  Zhang, Yifan;  Jian, Yong;  Zhao, Qianyu 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 LC-MS/MS  Alflutinib  AST2818  Pharmacokinetics  Human plasma   Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 20, 页码: 8951-8952 作者:  Chang, Yu;  Xu, Shilin;  Ding, Ke 收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 SHR-A1403, a novel c-mesenchymal-epithelial transition factor (c-Met) antibody-drug conjugate, overcomes AZD9291 resistance in non-small cell lung cancer cells overexpressing c-Met 期刊论文 CANCER SCIENCE, 2019, 页码: 11 作者:  Tong, Mengya;  Gao, Mingzhao;  Xu, Yongping;  Fu, Li;  Li, Yun 收藏  |  浏览/下载：21/0  |  提交时间：2020/07/01 AZD9291  c-Met ADC  c-Met overexpression  resistance  SHR-A1403   Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395 作者:  Diao, Yanyan;  Fang, Xiaoyu;  Song, Peiran;  Lai, Mengzhen;  Tong, Linjiang 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 Bruton's tyrosine kinase  B-cell malignancies  Potent inhibitors  Structure-activity relationship  Cellular activities   SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 7, 页码: 971-979 作者:  Yang, Chang-yong;  Wang, Lei;  Sun, Xing;  Tang, Mi;  Quan, Hai-tian 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 SHR-A1403  c-Met ADC  anti-tumor  patient-derived xenograft (PDX)  molecular mechanisms   Design, synthesis and biological study of potent and covalent HER-2 tyrosine kinase inhibitors with low cytotoxicity in vitro 期刊论文 CHEMICAL PAPERS, 2019, 卷号: 73, 期号: 6, 页码: 1333-1345 作者:  Jin, Shuyu;  Sun, Xiuyun;  Liu, Dan;  Xie, Hua;  Rao, Yu 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 HER-2 inhibitors  4-Anilino-3-cyanoquinoline  Covalent  Anticancer activity   Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and and in vivo study 期刊论文 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 351-368 作者:  Wei, Peng;  Liu, Bo;  Wang, Ruifeng;  Gao, Yinglei;  Li, Lanlan 收藏  |  浏览/下载：103/0  |  提交时间：2020/07/01 Fibroblast growth factor  Tyrosine kinase receptor  Structure-based  Crystallography  Selectivity  Hybrid  5-Hydrosulfonyl-5H- pyrrolo[2.3-b]pyrazine  Inhibitor   2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells 期刊论文 BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 卷号: 19, 页码: 13 作者:  Li, Wuguo;  Zhang, Qing;  Chen, Kaotan;  Sima, Zhenhua;  Liu, Jingli 收藏  |  浏览/下载：10/0  |  提交时间：2020/07/01 Polygonum cuspidatum  2-Ethoxystypandrone  Hepatocellular carcinoma  Cancer stem cells  STAT3 signaling pathway  Cancer stemness inhibitor   3deoxy216dihydroxynagilactoneeanaturalcompoundfrompodocarpusnagipreferentiallyinhibitsjak2stat3signalingbyallostericallyinteractingwiththeregulatorydomainofjak2andinducesapoptosisofcancercells 期刊论文 actapharmacologicasinica, 2019, 卷号: 40, 期号: 12, 页码: 1578 作者:  Shan Hui;  Yao Sheng;  Ye Yang;  Yu Qiang 收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01 JAK/STAT  3-deoxy-2β  16-dihydroxynagilactone E  tyrosine kinase inhibitor  allosteric inhibitor  cancer