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浏览/检索结果: 共45条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791 作者:  Guo, Bin;  Guo, Shimeng;  Huang, Jing;  Li, Jingya;  Li, Jia 收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 GPR40 agonist  2,3-Dihydrobenzo[b][1,4]dioxine  Insulin secretion  Type 2 diabetes mellitus   Identification of a cellularly active SIRT6 allosteric activator 期刊论文 NATURE CHEMICAL BIOLOGY, 2018, 卷号: 14, 期号: 12, 页码: 1118-+ 作者:  Huang, Zhimin;  Zhao, Junxing;  Deng, Wei;  Chen, Yingyi;  Shang, Jialin 收藏  |  浏览/下载：89/0  |  提交时间：2019/01/08 Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 6, 页码: 1998-2008 作者:  Zhong, Li;  Liu, Qing;  Ting, Yan Sie;  Vun Yien Thien;  Kalong, Nurwafa Syafiqah Binti 收藏  |  浏览/下载：89/0  |  提交时间：2019/01/08 adenine derivative  structural optimization  thioredoxin-binding protein-2  thioredoxin-interacting protein  vitamin D3-upregulated protein-1   Personalized Medicines Molecular Signature-Based Drug Discovery and Development, Strategic Priority Research Program of Chinese Academy of Sciences[XDA12040307] 项目 项目编号: XDA12040307, 资助机构: Personalized Medicines Molecular Signature-Based Drug Discovery and Development, Strategic Priority Research Program of Chinese Academy of Sciences, 2018- - 收藏  |  浏览/下载：0/0  |  提交时间：2020/07/01 Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Programof Chinese Academy of Sciences[XDA12020347] 项目 项目编号: XDA12020347, 资助机构: Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Programof Chinese Academy of Sciences, 2018- - 收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01 Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Programof Chinese Academy of Sciences[XDA12040308] 项目 项目编号: XDA12040308, 资助机构: Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Programof Chinese Academy of Sciences, 2018- - 收藏  |  浏览/下载：2/0  |  提交时间：2020/07/01 Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1768-1776 作者:  Liu, Ying-Qiang;  Wang, Ya-Nan;  Lu, Xiao-Yun;  Tong, Lin-Jiang;  Li, Yan 收藏  |  浏览/下载：110/0  |  提交时间：2019/01/08 CSF-1R  small-molecule inhibitor  macrophage  myeloid leukemia   A new class of HIV-1 inhibitors and the target identification via proteomic profiling 期刊论文 SCIENCE CHINA-CHEMISTRY, 2018, 卷号: 61, 期号: 11, 页码: 1430-1439 作者:  Ge, Ying-Zi;  Zhou, Bin;  Xiao, Ruo-Xuan;  Yuan, Xiao-Jing;  Zhou, Hu 收藏  |  浏览/下载：183/0  |  提交时间：2019/01/08 ergostane-type steroids  anti-HIV  target identification  PKM2   Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020321] 项目 项目编号: XDA12020321, 资助机构: Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences, 2018- - 收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01 Personalized Medicines, Molecular Signature-based Drug Discovery and Development 项目 资助机构: Personalized Medicines, Molecular Signature-based Drug Discovery and Development, 2018- - 收藏  |  浏览/下载：5/0  |  提交时间：2020/07/01