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浏览/检索结果: 共20条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Identification of a cellularly active SIRT6 allosteric activator 期刊论文 NATURE CHEMICAL BIOLOGY, 2018, 卷号: 14, 期号: 12, 页码: 1118-+ 作者:  Huang, Zhimin;  Zhao, Junxing;  Deng, Wei;  Chen, Yingyi;  Shang, Jialin 收藏  |  浏览/下载：91/0  |  提交时间：2019/01/08 The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine 期刊论文 MOLECULAR GENETICS AND METABOLISM REPORTS, 2018, 卷号: 17, 页码: 46-52 作者:  Li, Hong;  Zhao, Lihua;  Singh, Rani;  Ham, J. Nina;  Fadoju, Doris O. 收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08 Glucagon receptor  Newborn screening  GCGR mutation  Hyperaminoacidemia  Mahvash disease  Pancreatic alpha cell hyperplasia (ACH)  Pancreatic neuroendocrine tumor (PNET)   Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 281-294 作者:  Xing, Jing;  Zhang, Rukang;  Jiang, Xiangrui;  Hu, Tianwen;  Wang, Xinjun 收藏  |  浏览/下载：88/0  |  提交时间：2019/01/08 Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20, 页码: 5397-5407 作者:  Lu, Wenchao;  Xiong, Huan;  Chen, Yu;  Wang, Chen;  Zhang, Hao 收藏  |  浏览/下载：140/0  |  提交时间：2019/01/08 Drug discovery  Epigenetics  Histone acetyltransferase  P300/CBP   Metabolism and disposition of pyrotinib in healthy male volunteers: covalent binding with human plasma protein 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Meng, Jian;  Liu, Xiao-Yun;  Ma, Sheng;  Zhang, Hua;  Yu, Song-da 收藏  |  浏览/下载：99/0  |  提交时间：2019/01/08 Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654 作者:  Zhang, Li;  Chen, Yantao;  Liu, Na;  Li, Linjuan;  Xiao, Senhao 收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 Pyrimidylaminoquinoline  Nonnucleoside DOT1L inhibitors  Amino side chains  Mixed-linage leukemia  Histone lysine methyltransferase   Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 867-876 作者:  Zhang, Rukang;  Wang, Jiang;  Zhao, Liang;  Liu, Shien;  Du, Daohai 收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 High throughput screening  Epigenetics  Histone acetyltransferase  MOF  Inhibitor   Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 9, 页码: 1544-1552 作者:  Lu, Tian;  Hu, Jun-chi;  Lu, Wen-chao;  Han, Jie;  Ding, Hong 收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 AlphaScreen  high-throughput screening  SMARCA2  bromodomain  small molecule inhibitor   Protein Acylation is a General Regulatory Mechanism in Biosynthetic Pathway of Acyl-CoA-Derived Natural Products 期刊论文 CELL CHEMICAL BIOLOGY, 2018, 卷号: 25, 期号: 8, 页码: 984-+ 作者:  Xu, Jun-Yu;  Xu, Ya;  Xu, Zhen;  Zhai, Lin-Hui;  Ye, Yang 收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 The mimics of N-epsilon-acyl-lysine derived from cysteine as sirtuin inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 14, 页码: 2375-2378 作者:  Wang, Chun;  Wang, Fang;  Chen, Xiaoxue;  Zou, Yefang;  Zhu, Hong 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 L-Cysteine  The mimics of lysine  Mechanism-based inhibitors  Sirtuin inhibitors  SIRT2 inhibitors