cardiac glycoside  acetylthevetin B  antitumor  lung cancer  polymeric micelle  drug delivery  A549 xenograft tumor model  

AIs  aromatase inhibitors  AMPK  Adenosine Monophosphate-Activated Protein Kinase  AR  androgen  ATM  Ataxia Telangiectasia Mutated  ATP  Adenosine Triphosphate  BCSS  breast cancer specific survival  CK-MB  Creatine Kinase-MB  CREB1  cAMP Response Element-Binding Protein 1  CSC  cancer stem cell  DFS  disease-free survival  DHFU  dihydrofluorouracil  DPD  dihydropyrimidine dehydrogenase  EpCAM  Epithelial Cell Adhesion Molecule  ER  estrogen  ERCC1  excision repair cross-complementary 1  ERK  extracellular signal-regulated kinases  EZH2  enhancer of zeste homolog 2  FdUMP  fluorodeoxyuridine monophosphate  FdUTP  fluorodeoxyuridine triphosphate  FHC  ferritin heavy chain  FUTP  fluorouridine triphosphate  HbA1C  hemoglobin A1c  HER  Human Epidermal Growth Factor Receptor  HIF-1α  hypoxia-inducible factor-1α  HK  hexokinase  IGF1R  insulin growth factor 1 receptor  LDH  lactate dehydrogenase  MDA  Muscular Dystrophy Association  MMP  Matrix Metallopeptidase  MRP1  multidrug resistance-associated protein 1  mTOR  mammalian target of rapamycin  MTX  methotrexate  NCCN  National Comprehensive Cancer Network  OS  overall survival  pCR  Pathologic Complete Response  PDGFR  platelet-derived growth factor receptors  PFS  progression-free survival  PKA  protein kinase A  PR  progesterone receptor  RFS  relapse-free survival  SOD  superoxide dismutase  TAM  tamoxifen  TCA  tricarboxlic acid  TS  thymidylate synthase  Combination  Mechanisms  Metformin  Chemotherapeutic drugs  

MRP2  metabolism  pharmacokinetic  transport  β-carboline alkaloid  

UAAs  unnatural amino acids  Rd  rubredoxin  EPR  electron paramagnetic resonance  Az  azurin  SOR  superoxide reductase  PDB  protein data bank  6-PGLac  6-phosphogluconolactonase  H-bond  hydrogen-bond  NIR  nitrite reductase  ET  electron transfer  3SCC  three stranded coiled coil  Bpy-Ala  (2,2′-bipyridinine-5-yl)alanine  CcO  cytochrome c oxidase  N2OR  nitrous oxidase reductase  XANES  X-ray absorption near-edge structure  DF  Due Ferri  4-AP  4-amino-phenol  POP  prolyl oligopeptidase  ee  enantiomeric excess  HCO  heme-copper oxidase  NOR  nitric oxide reductase  MnP  manganese peroxidase  Mb  myoglobin  RFQ-rR  freeze-quench resonance Raman  CcP  Cyt c peroxidase  BMC  microcompartment  CYP  cytochrome P450  TON  turnover number  TDHC  tetradehydrocorrin  NB  nitrobindin  RCM  ring-closing metathesis  ROMP  ring-opening metathesis polymerization  SAV  steptavidin  NCS  neocarzinostatin  BLG  -Lactoglobulin  HSA  human serum albumin  BSA  bovine serum albumin  ITC  isothermal titration calorimetry  AldO  alditol oxidase  FAD  flavin adenine dinucleotide  MP  microperoxidase  HB  heme-binding  GTL  Geobacillus thermocatenulatus lipase  4NPA  4-nitrophenyl acetate  LmrR  Lactococcal multidrug resistance Regulator  ABTS  2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt  mCPBA  meta-chloroperbenzoic acid  Fd  ferredoxin  Fld  flavodoxin  HTHP  hexameric Tyr-coordinated heme protein  AFM  atomic force microscopy  TEM  transmission electron microscopy  MRI  magnetic resonance imaging  Metalloproteins  Metalloenzymes  Protein design  Multiple active sites  Biocatalysts