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浏览/检索结果: 共7条，第1-7条 帮助 限定条件 发表日期：2017     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文 ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990 作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 BEZ235  drug resistance  mTOR  PI3K  SHR8443   PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KII alpha, Inhibits the Growth of Breast Cancer Cells 期刊论文 CANCER RESEARCH, 2017, 卷号: 77, 期号: 22, 页码: 6253-6266 作者:  Li, Jiangmei;  Gao, Zhen;  Zhao, Dan;  Zhang, Lunfeng;  Qiao, Xinhua 收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08 New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound 期刊论文 SCIENTIFIC REPORTS, 2017, 卷号: 7 作者:  Yang, Xiuyan;  Zhang, Xi;  Huang, Min;  Song, Kun;  Li, Xuefen 收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity 期刊论文 ACS MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 8, 期号: 8, 页码: 875-880 作者:  Yang, Chengbin;  Zhang, Xi;  Wang, Yi;  Yang, Yongtai;  Liu, Xiaofeng 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 PI3K  PI3K/mTOR  oncology  1H-pyrrolo[2,3-b] pyridine  cancer therapy   AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 489, 期号: 1, 页码: 14-20 作者:  Wang, Hongbin;  Quan, Haitian;  Lou, Liguang 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Antagonism  AKT  BRAF  Dabrafenib  Sorafenib   Enantioselective Total Synthesis of (+)-Wortmannin 期刊论文 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017 Guo, Yinliang; Quan, Tianfei; Lu, Yandong; Luo, Tuoping 收藏  |  浏览/下载：4/0  |  提交时间：2017/12/03 PHOSPHOINOSITIDE 3-KINASE  PHOSPHATIDYLINOSITOL 3-KINASE  CONCISE SYNTHESIS  SELECTIVE METHOD  WORTMANNIN  KINASE  INHIBITION  OXIDATION  (+)-XESTOQUINONE  LY294002   Airborne nitro-PAHs induce Nrf2/ARE defense system against oxidative stress and promote inflammatory process by activating PI3K/Akt pathway in A549 cells 期刊论文 TOXICOLOGY IN VITRO, 2017 Shang, Yu; Zhou, Qian; Wang, Tiantian; Jiang, Yuting; Zhong, Yufang; Qian, Guangren; Zhu, Tong; Qiu, Xinghua; An, Jing 收藏  |  浏览/下载：11/0  |  提交时间：2017/12/03 Nitro-PAHs  Oxidative stress  Cytokines  Nrf2/ARE  PI3K/Akt  POLYCYCLIC AROMATIC-HYDROCARBONS  AMBIENT PARTICULATE MATTER  AIR-POLLUTION  DNA-DAMAGE  SIGNALING PATHWAY  DIESEL EXHAUST  NITRATED-PAHS  IN-VITRO  EXPOSURE  HEALTH