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Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping
收藏  |  浏览/下载:42/0  |  提交时间:2019/06/17
Design, synthesis and biological evaluation of indolin-2-one-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase3 (FLT3) 期刊论文
European journal of medicinal chemistry, 2017, 卷号: 127, 页码: 72-86
作者:  Ma, Fei;  Liu, Peng;  Lei, Min;  Liu, Jian;  Wang, Hongtao
收藏  |  浏览/下载:12/0  |  提交时间:2019/01/08
Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6 期刊论文
2017, 卷号: 8, 期号: 61, 页码: 103087-103099
作者:  Li, Yu-Zhi[1,2];  Yu, Si[1,2];  Yan, Pei-Ao[1,2];  Gong, Dao-Yin[1,2];  Wu, Fang-Li[3]
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/06
A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220 期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 16
作者:  Hou, Panpan;  Wu, Chao;  Wang, Yuchen;  Qi, Rui;  Bhavanasi, Dheeraj
收藏  |  浏览/下载:2/0  |  提交时间:2019/12/05
MZH29 is a novel potent inhibitor that overcomes drug resistance FLT3 mutations in acute myeloid leukemia 期刊论文
2017, 卷号: 31, 期号: 4, 页码: 913-921
作者:  Xu, B.;  Zhao, Y.;  Wang, X.;  Gong, P.;  Ge, W.
收藏  |  浏览/下载:2/0  |  提交时间:2020/01/03


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