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浏览/检索结果: 共34条，第1-10条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design, synthesis and biological evaluation of novel alpha-hederagenin derivatives with anticancer activity 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 427-439 作者:  Liu, Xian-xuan;  Yang, Yan-ting;  Wang, Xiao;  Wang, Kai-yi;  Liu, Jia-qi 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 alpha-Hederagenin derivatives  Synthesis  Apoptosis  Cancer   Design and synthesis of Atglistatin derivatives as adipose triglyceride lipase inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1122-1133 作者:  Jin, Jiyu;  Huang, Suling;  Wang, Lei;  Leng, Ying;  Lu, Wei 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 adipose triglyceride lipase inhibitors  Atglistatin  structure-activity relationship  thiourea   Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721 作者:  Li, Xiaokang;  Wang, Huan;  Xu, Yixiang;  Liu, Wenwen;  Gong, Qi 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Alzheimer's disease  depression  multitarget-directed ligand  ChE inhibition  5-HT1A agonist  5-HT reuptake inhibition   Design, Synthesis, and Evaluation of Ribose-Modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors 期刊论文 FRONTIERS IN CHEMISTRY, 2017, 卷号: 5 作者:  Hu, Xiuqin;  Wang, Disha;  Tong, Yi;  Tong, Linjiang;  Wang, Xia 收藏  |  浏览/下载：62/0  |  提交时间：2019/01/08 EGFR  tyrosine kinase inhibitors  anilinopyrtmidine  glycosides  carbohydrate-based drugs   Design, synthesis and. biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5 '-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 448-464 作者:  Zhou, Shengbin;  Duan, Yanan;  Wang, Jiang;  Zhang, Jin;  Sun, Haifeng 收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 Tetrahydroberberine  4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines  Mitochondrial respiration  AMPK indirect activators  db/db mice   Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 510-527 作者:  Chen, Lingfeng;  Fu, Weitao;  Feng, Chen;  Qu, Rong;  Tong, Linjiang 收藏  |  浏览/下载：55/0  |  提交时间：2019/01/08 Epidermal growth factor receptor  Tyrosine kinase inhibitors  Non-small cell lung cancer  T790M  Mutant-selective   Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer 期刊论文 BIOMATERIALS, 2017, 卷号: 144, 页码: 60-72 作者:  Hu, Chunhua;  Liu, Xiaoyu;  Ran, Wei;  Meng, Jia;  Zhai, Yihui 收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 Self-assembly  Hydrogel  Cancer associated fibroblasts  Metastasis  Triple negative breast cancer   Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 页码: 128-152 作者:  Wang, Zhengyu;  Shi, Xiaofan;  Zhang, Huan;  Yu, Liang;  Cheng, Yanhua 收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 Type 2 diabetes mellitus  Hypoglycemia  Dyslipidemia  Glucokinase activators  N-Thiazol-2-yl-benzamides   Design and synthesis of pregnenolone/2-cyanoacryloyl conjugates with dual NF-kappa B inhibitory and anti-proliferative activities 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 20, 页码: 4682-4686 作者:  Song, Jia-Li;  Zhang, Juan;  Liu, Chang-Liang;  Liu, Chao;  Zhu, Kong-Kai 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 Pregnenolone  NF-kappa B  2-Cyanoacryloyl  Michael acceptor  Anti-proliferative activity   Asymmetric Synthesis of Chiral Trifluoromethyl Containing Heterocyclic Amino Acids 期刊论文 CHINESE JOURNAL OF CHEMISTRY, 2017, 卷号: 35, 期号: 10, 页码: 1540-1548 作者:  Zhao, Liang;  Zhou, Shengbin;  Tong, Junhua;  Wang, Jiang;  Liu, Hong 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 trifluoromethyl containing heterocyclic amino acids  Ni(II)-complex of glycine  asymmetric Michael addition  alpha,beta-unsaturated ketones