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科研机构
上海药物研究所 [10]
内容类型
期刊论文 [10]
发表日期
2017 [10]
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发表日期:2017
专题:上海药物研究所
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A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 卷号: 61, 期号: 10
作者:
Kirby, Karen A.
;
Myshakina, Nataliya A.
;
Christen, Martin T.
;
Chen, Yue-Lei
;
Schmidt, Hilary A.
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
RNase H
human immunodeficiency virus
inhibitor
reverse transcriptase
Amyloid beta: structure, biology and structure-based therapeutic development
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 9, 页码: 1205-1235
作者:
Chen, Guo-fang
;
Xu, Ting-hai
;
Yan, Yan
;
Zhou, Yu-ren
;
Jiang, Yi
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 133, 页码: 85-96
作者:
Tang, Jing
;
Vernekar, Sanjeev Kumar V.
;
Chen, Yue-Lei
;
Miller, Lena
;
Huber, Andrew D.
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
2-hydroxyisoquinoline-1,3-diones
HIV
RNase H
Reverse transcriptase
Inhibitor
m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
期刊论文
CELL REPORTS, 2017, 卷号: 18, 期号: 11, 页码: 2622-2634
作者:
Cui, Qi
;
Shi, Hailing
;
Ye, Peng
;
Li, Li
;
Qu, Qiuhao
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Fabrication of stable galactosylated alginate microcapsules via covalent coupling onto hydroxyl groups for hepatocytes applications
期刊论文
CARBOHYDRATE POLYMERS, 2017, 卷号: 155, 页码: 456-465
作者:
Lou, Ruyun
;
Yu, Weiting
;
Song, Yizhe
;
Ren, Ying
;
Zheng, Huizhen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Galactosylated alginate
Hydroxyl groups
Microcapsules
Primary hepatocytes
Biological artificial liver support systems
Emerging and Diverse Functions of the EphA2 Noncanonical Pathway in Cancer Progression
期刊论文
Biological & pharmaceutical bulletin, 2017, 卷号: 40, 期号: 10, 页码: 1616-1624
作者:
Zhou, Yue
;
Sakurai, Hiroaki
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
High-Yield Synthesis of Monomeric LMWP(CPP)-siRNA Covalent Conjugate for Effective Cytosolic Delivery of siRNA
期刊论文
THERANOSTICS, 2017, 卷号: 7, 期号: 9, 页码: 2495-2508
作者:
Ye, Junxiao
;
Liu, Ergang
;
Gong, Junbo
;
Wang, Jianxin
;
Huang, Yongzhuo
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
cell penetrating peptide
siRNA delivery
covalent CPP-siRNA chemical conjugate
mass preparation
Research progress on protein tyrosine sulfation
期刊论文
Chinese Bulletin of Life Sciences, 2017, 卷号: 29, 期号: 2, 页码: 153-159
作者:
Pan Lulu
;
Zhai Linhui
;
Tan Minjia
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/01/08
post-translational modification
protein tyrosine sulfation
tyrosylprotein sulfotransferase
biological function
amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 9, 页码: 1205
作者:
Chen Guofang
;
Xu Tinghai
;
Yan Yan
;
Zhou Yuren
;
Jiang Yi
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
BLOOD-BRAIN-BARRIER
INSULIN-DEGRADING ENZYME
SOLID-STATE NMR
NICOTINIC ACETYLCHOLINE-RECEPTORS
METABOTROPIC GLUTAMATE RECEPTORS
ATOMIC-FORCE MICROSCOPY
GAMMA-SECRETASE COMPLEX
SMOOTH-MUSCLE-CELLS
AMELIORATES MEMORY IMPAIRMENT
ENDOTHELIN-CONVERTING ENZYME
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
Differential function analysis: identifying structure and activation variations in dysregulated pathways
期刊论文
Science China. Information Science, 2017, 卷号: 60, 期号: 1
作者:
Chen Luonan
;
Zeng Tao
;
Shi Qianqian
;
Zhang Chuanchao
;
Liu Juan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
NONNEGATIVE MATRIX FACTORIZATION
EARLY-WARNING SIGNALS
COMPLEX DISEASES
MICROARRAY DATA
GASTRIC-CANCER
MODULE NETWORK
PREDICTION
DISCOVERY
ONTOLOGY
NOISE
complex disease
biological function
non-negative matrix factorization
network structure
function activation
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