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Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 15, 页码: 7111-7124
作者:  Hao, Yongjia;  Wang, Xia;  Zhang, Tao;  Sun, Deheng;  Tong, Yi
收藏  |  浏览/下载:32/0  |  提交时间:2019/01/08
Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment 期刊论文
CANCER LETTERS, 2016, 卷号: 380, 期号: [db:dc_citation_issue], 页码: 494-504
作者:  Shi, Puyu;  Oh, You Take;  Zhang, Guojing;  Yao, Weilong;  Yue, Ping
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/02
Bim  EGFR  Resistance  AZD9291  Met  Erlotinib  
Targeting non-canonical autophagy overcomes erlotinib resistance in tongue cancer 期刊论文
TUMOR BIOLOGY, 2016, 卷号: 37, 期号: 7, 页码: 9625-9633
作者:  huang, Keqiang;  liu, Dongxu
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/17
Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer 期刊论文
CELL DISCOVERY, 2016, 卷号: 2
作者:  Li, Hongde;  Stokes, William;  Chater, Emily;  Roy, Rajat;  de Bruin, Elza
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/06


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