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浏览/检索结果: 共58条，第1-10条 帮助 限定条件 发表日期：2016    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis 期刊论文 CELL RESEARCH, 2016, 卷号: 26, 期号: 12, 页码: 1330-1344 作者:  Zhang, Lin;  Xiao, Jianfeng;  Xu, Jianrong;  Fu, Tianran;  Cao, Zhiwei 收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 fatty acid biosynthesis  dehydratase  ACP  complex structure   Characterization of Protein Lysine Propionylation in Escherichia coli: Global Profiling, Dynamic Change, and Enzymatic Regulation 期刊论文 JOURNAL OF PROTEOME RESEARCH, 2016, 卷号: 15, 期号: 12, 页码: 4696-4708 作者:  Sun, Mingwei;  Xu, Junyu;  Wu, Zhixiang;  Zhai, Linhui;  Liu, Chengxi 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 post-translational modification(s)  lysine propionylation  SILAC  CobB  PatZ   Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 23, 页码: 6206-6214 作者:  Zhang, Jiankang;  Gao, Lixin;  Xi, Jianjun;  Sheng, Li;  Zhao, Yanmei 收藏  |  浏览/下载：51/0  |  提交时间：2019/01/08 Proteasome inhibitors  Piperidine  Non-covalent  Anti-cancer  SARs   A historic study that opened a new chapter in nutritional science 期刊论文 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 12, 页码: 1641-1644 作者:  Lei, Sai-fei;  Yang, De-hua;  Wang, Ming-wei 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain 期刊论文 CELL DISCOVERY, 2016, 卷号: 2 作者:  Yin, Yanting;  Zhou, X. Edward;  Hou, Li;  Zhao, Li-Hua;  Liu, Bo 收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 GLP-1R  class B GPCR  intrinsic agonist  glucagon-like peptide-1  exendin-4  BETP   Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 22, 页码: 5399-5402 作者:  Han, Mei;  Wang, Chengyan;  Ji, Yinchun;  Song, Zilan;  Xing, Li 收藏  |  浏览/下载：66/0  |  提交时间：2019/01/08 EML4-ALK kinase  Oxidative metabolism  Benzo[b]carbazolone  hERG  Antitumor activity   Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection 期刊论文 DRUG METABOLISM AND DISPOSITION, 2016, 卷号: 44, 期号: 11, 页码: 1853-1858 作者:  Cheng, Chen;  Du, Feifei;  Yu, Ke;  Xu, Fang;  Wang, Fengqing 收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons 期刊论文 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 11, 页码: 1391-1400 作者:  Tao, Ling-xue;  Huang, Xiao-tian;  Chen, Yu-ting;  Tang, Xi-can;  Zhang, Hai-yan 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Alzheimer's disease  huperzine A  iron  reactive oxygen species  mitochondria dysfunction  acetylcholinesterase   Facile Synthesis of 7-epi-Taxane and Its Derivatives and Preliminary Evaluation of Anticancer Activity 期刊论文 CHINESE JOURNAL OF CHEMISTRY, 2016, 卷号: 34, 期号: 11, 页码: 1165-1176 作者:  Li, Zhao;  Feng, Jia;  Zou, Kun;  Yang, Zhuo;  Zhang, Yong 收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 taxane  7-epi-taxane  silver oxide  amino acid  C-13 derivative of taxane  anticancer activity   Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry 期刊论文 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1033, 页码: 117-127 作者:  Zhu, Yunting;  Li, Liang;  Zhang, Ge;  Wan, Hong;  Yang, Changyong 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Pyrotinib  UPLC/Q-TOF MS  Metabolism  Human  CYP3A4  Drug-drug interaction