Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media

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	Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media
	Liu, Yang1,2 ; Li, Xiao-Ming 1; Meng, Ling-Hong1,2 ; Jiang, Wen-Li 3; Xu, Gang-Ming 1; Huang, Cai-Guo 3; Wang, Bin-Gui1
刊名	JOURNAL OF NATURAL PRODUCTS
	2015-06-01
卷号	78 期号:6 页码:1294-1299
英文摘要	Chemical investigation of the marine-sponge-derived fungus Penicillium adametzioides AS-53 resulted in the identification of two new bisthiodiketopiperazine derivatives, adametizines A (1) and B (2), from cultivation in a liquid potato-dextrose broth (PDB) culture medium, whereas two new acorane sesquiterpenes, adametacorenols A (3) and B (4), were isolated from a rice solid culture medium. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The absolute configuration of compound 1 was determined by X-ray crystallographic analysis, and that of 3 was determined by modified Mosher's method. Compound 1 exhibited lethality against brine shrimp (Artemia salina) with an LD50 value of 4.8 mu M and inhibitory activities against Staphyloccocus aureus, Aeromonas hydrophilia, Vibrio spp. V. harveyi and V. parahaemolyticus, and Gaeumannomyces graminis with minimum inhibitory concentration values of 8, 8, 32, 8, and 16 mu g/mL, respectively. Chlorination at C-7 significantly increased the brine shrimp lethality and antimicrobial activity of the bisthiodiketopiperazines.
收录类别	SCI
语种	英语
WOS记录号	WOS:000357138300014
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/49046]
专题	海洋研究所_实验海洋生物学重点实验室海洋研究所_海洋生态与环境科学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yang,Li, Xiao-Ming,Meng, Ling-Hong,et al. Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(6):1294-1299.
APA	Liu, Yang.,Li, Xiao-Ming.,Meng, Ling-Hong.,Jiang, Wen-Li.,Xu, Gang-Ming.,...&Wang, Bin-Gui.(2015).Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media.JOURNAL OF NATURAL PRODUCTS,78(6),1294-1299.
MLA	Liu, Yang,et al."Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media".JOURNAL OF NATURAL PRODUCTS 78.6(2015):1294-1299.