Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study
	Zhang, Hui 1,2; Huang, Mingming 1,3; Gao, Lifeng 1; Lei, Hao 1
刊名	JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
	2015-11-01
卷号	35 期号:11 页码:1738-1745
关键词	animal modelsbrain imaging diabetes hyperglycemia MR spectroscopy
英文摘要	Clinical and experimental in vivo H-1-magnetic resonance spectroscopy (H-1-MRS) studies have demonstrated that type 1 diabetes mellitus (T1DM) is associated with cerebral metabolic abnormalities. However, less is known whether T1DM induces different metabolic disturbances in different brain regions. In this study, in vivo H-1-MRS was used to measure metabolic alterations in the visual cortex, striatum, and hippocampus of streptozotocin (STZ)-induced uncontrolled T1DM rats at 4 days and 4 weeks after induction. It was observed that altered neuronal metabolism occurred in STZ-treated rats as early as 4 days after induction. At 4 weeks, T1DM-related metabolic disturbances were clearly region specific. The diabetic visual cortex had more or less normal-appearing metabolic profile; while the striatum and hippocampus showed similar abnormalities in neuronal metabolism involving N-acetyl aspartate and glutamate; but only the hippocampus exhibited significant changes in glial markers such as taurine and myo-inositol. It is concluded that cerebral metabolic perturbations in STZ-induced T1DM rats are region specific at 4 weeks after induction, perhaps as a manifestation of varied vulnerability among the brain regions to sustained hyperglycemia.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Endocrinology & Metabolism ; Hematology ; Neurosciences
研究领域[WOS]	Endocrinology & Metabolism ; Hematology ; Neurosciences & Neurology
关键词[WOS]	BRAIN ENERGY-METABOLISM ; MR SPECTROSCOPY ; MITOCHONDRIAL DYSFUNCTION ; N-ACETYLASPARTATE ; HIPPOCAMPUS ; MELLITUS ; HYPERGLYCEMIA ; HYPOGLYCEMIA ; RETINOPATHY ; PROFILE
收录类别	SCI
语种	英语
WOS记录号	WOS:000364259900005
公开日期	2015-12-22
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9049]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Guiyang Med Univ, Affiliated Hosp, Dept Radiol, Guiyang, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hui,Huang, Mingming,Gao, Lifeng,et al. Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2015,35(11):1738-1745.
APA	Zhang, Hui,Huang, Mingming,Gao, Lifeng,&Lei, Hao.(2015).Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,35(11),1738-1745.
MLA	Zhang, Hui,et al."Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 35.11(2015):1738-1745.