Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 水生生物分子与细胞生物学研究中心 > 期刊论文

	Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily
	Xiong, Jie 1; Feng, Jinmei 1; Yuan, Dongxia 1; Zhou, Jun 2; Miao, Wei 1
刊名	SCIENTIFIC REPORTS
	2015-11-18
卷号	5
ISSN号	2045-2322
英文摘要	The ATP binding cassette (ABC) transporters superfamily is one of the largest classes of membrane proteins. The core of the ABC transporter protein is composed of transmembrane domains (TMDs) and nucleotide binding domains (NBD). Eukaryotes ABC transporters are classified into seven main families (ABCA to ABCG) based on sequence similarity and domain organizations. With different domain number and domain organizations, eukaryote ABC transporters show diverse structures: the single structure (NBD or TMD), the ABC2 structure (NBD-NBD), the half structure (TMD-NBD or NBD-TMD) and the full structure (TMD-NBD-TMD-NBD or NBD-TMD-NBD-TMD). However, studies on how various ABC transporter gene structures evolved is still absent. Therefore, in this study, we comprehensively investigated the structural evolution of eukaryotic ABC transporters. The seven eukaryote ABC transporter families (A to G) fell into three groups: A& G group, B, C& D group and E& F group. There were at least four times the number of NBD and TMD fusion events in the origin of the half structure transporter. Two fusion modes were found in the full and ABC2 structure origination. Based on these findings, we present a putative structural evolutionary path of eukaryote ABC transporters that will increase our understanding on their origin, divergence and function.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	MULTIPLE SEQUENCE ALIGNMENT ; ABC TRANSPORTER ; GENE DUPLICATION ; ESCHERICHIA-COLI ; CAENORHABDITIS-ELEGANS ; DRUG-RESISTANCE ; ARGININE KINASE ; FAMILY ; FUSION ; OPERON
收录类别	SCI
语种	英语
WOS记录号	WOS:000364843900001
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/27353]
专题	水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 2.Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA
推荐引用方式 GB/T 7714	Xiong, Jie,Feng, Jinmei,Yuan, Dongxia,et al. Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily[J]. SCIENTIFIC REPORTS,2015,5.
APA	Xiong, Jie,Feng, Jinmei,Yuan, Dongxia,Zhou, Jun,&Miao, Wei.(2015).Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily.SCIENTIFIC REPORTS,5.
MLA	Xiong, Jie,et al."Tracing the structural evolution of eukaryotic ATP binding cassette transporter superfamily".SCIENTIFIC REPORTS 5(2015).