A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release

	A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release
	He, Shasha 1,2; Cong, Yuwei 1,2; Zhou, Dongfang 1; Li, Jizhen 3; Xie, Zhigang 1; Chen, Xuesi 4; Jing, Xiabin 1; Huang, Yubin 1
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2015
卷号	3 期号:41 页码:8203-8211
英文摘要	Reduction-responsive nano-carriers have been confirmed to be promising for intracellular drug delivery. To develop multifunctional polymer-based drug delivery system, a novel dextran-Pt(IV) conjugate was synthesized by conjugating Pt(IV) to the side chains of the hydrophilic dextran and used for doxorubicin (DOX) delivery. Pt(IV) conjugation could change the hydrophilicity of dextran, leading to the self-assembly of dextran-Pt(IV) conjugates with different morphologies. Pt(IV) segments served as the key components in assembly formation and as the antitumor prodrug. Under a reductive environment, Pt(IV) was found to be reduced to its active Pt(II) form and cleaved from dextran, shifting the hydrophilic-hydrophobic balance of the dextran-Pt(IV) conjugate. The collapse of the assembly structure due to the partial or complete recovery of the hydrophilicity of dextran led to triggered release of DOX. The DOX-loaded dextran-Pt(IV) conjugate obtained by combining the released hydrophobic DOX and recovered hydrophilic Pt(II), was found to be very effective as an antitumor agent as demonstrated in in vitro cytotoxicity evaluations. This DOX-loaded dextran-Pt(IV) conjugate system provided a new strategy to trigger the release of hydrophobic and hydrophilic drugs at the same time via single reduction-responsive control to provide an enhanced anti-tumor effect.
收录类别	SCI
语种	英语
公开日期	2015-12-22
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29161]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Jilin Univ, Coll Chem, Changchun 130023, Peoples R China 4.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	He, Shasha,Cong, Yuwei,Zhou, Dongfang,et al. A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(41):8203-8211.
APA	He, Shasha.,Cong, Yuwei.,Zhou, Dongfang.,Li, Jizhen.,Xie, Zhigang.,...&Huang, Yubin.(2015).A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release.JOURNAL OF MATERIALS CHEMISTRY B,3(41),8203-8211.
MLA	He, Shasha,et al."A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release".JOURNAL OF MATERIALS CHEMISTRY B 3.41(2015):8203-8211.