Asymmetric Organocatalytic Cascade Michael/Michael/Henry Reaction Sequence: Control of All Stereocenters in One Cyclohexane Skeleton

	Asymmetric Organocatalytic Cascade Michael/Michael/Henry Reaction Sequence: Control of All Stereocenters in One Cyclohexane Skeleton
	Mao, Zhifeng 1,2,3; Jia, Yaomei 1,2; Xu, Zhaoqing 3; Wang, Rui 1,2
刊名	advanced synthesis & catalysis
	2012-05-01
卷号	354 期号:8 页码:1401-1406
关键词	asymmetric catalysis cyclohexanes domino reactions Henry reaction Michael addition
英文摘要	the highly diastereo- and enantioselective relay cascade michael/michael/henry reaction catalyzed by combination of readily available diphenylprolinol silyl ether and the quinine thiourea in a one-pot fashion has been developed. up to 70% yield and up to >99% enantioselectivity of the single major isomer were obtained from the cascade reactions.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, applied ; chemistry, organic
研究领域[WOS]	chemistry
关键词[WOS]	diphenylprolinol silyl ether ; michael-henry reactions ; high-yielding synthesis ; functionalized cyclohexanes ; inhibitor (-)-oseltamivir ; contiguous stereocenters ; bifunctional thiourea ; tandem reactions ; bond donors ; catalysis
收录类别	SCI ; IC ; CCR
语种	英语
WOS记录号	WOS:000304345100003
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/142942]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Inst Biochem & Mol Biol,Sch Life Sci, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Mao, Zhifeng,Jia, Yaomei,Xu, Zhaoqing,et al. Asymmetric Organocatalytic Cascade Michael/Michael/Henry Reaction Sequence: Control of All Stereocenters in One Cyclohexane Skeleton[J]. advanced synthesis & catalysis,2012,354(8):1401-1406.
APA	Mao, Zhifeng,Jia, Yaomei,Xu, Zhaoqing,&Wang, Rui.(2012).Asymmetric Organocatalytic Cascade Michael/Michael/Henry Reaction Sequence: Control of All Stereocenters in One Cyclohexane Skeleton.advanced synthesis & catalysis,354(8),1401-1406.
MLA	Mao, Zhifeng,et al."Asymmetric Organocatalytic Cascade Michael/Michael/Henry Reaction Sequence: Control of All Stereocenters in One Cyclohexane Skeleton".advanced synthesis & catalysis 354.8(2012):1401-1406.