Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives

	Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives
	Zhou, Huo-Fei 2,3; Liu, Xiu-Dong 1; Zhang, Ying 2; Ma, Xiao-Jun 2
刊名	journal of nanoscience and nanotechnology
	2010-04-01
卷号	10 期号:4 页码:2304-2313
关键词	Chitosan Lithocholic Acid Quaternization Nanoaggregates
英文摘要	a novel kind of chitosan derivatives (cs-la-tm) were synthesized by grafting hydrophobic molecules of lithocholic acid (la) and quaternization. cs-la-tm and micelle-like self-aggregates were characterized by ftir, (1)h nmr, fluorescence spectroscopy, dynamic light scattering, and transmission electron microscopy (tem). the critical micelles concentration (cmc) ranging from 0.009 mg/ml to 0.030 mg/ml decreased with increasing of the degree of substitution (ds) of la, ph of medium but with decreasing of the degree of quaternization (dq) of amino groups. the tem images demonstrated that spherical cs-la-tm nanoaggregates with uniform size were formed by self-assembly. the sizes (100-200 nm) of cs-las-tms nanoaggregates increased with increasing of ds, do, and can be easily controlled by ph of medium, which may confer the nanoaggregates potential as delivery systems for anticancer drugs, or dna and sirna.
WOS标题词	science & technology ; physical sciences ; technology
类目[WOS]	chemistry, multidisciplinary ; nanoscience & nanotechnology ; materials science, multidisciplinary ; physics, applied ; physics, condensed matter
研究领域[WOS]	chemistry ; science & technology - other topics ; materials science ; physics
关键词[WOS]	drug-delivery ; aggregated nanoparticles ; polymeric micelles ; block-copolymer ; gene carrier ; in-vitro ; systems ; paclitaxel ; cytotoxicity ; release
收录类别	SCI
语种	英语
WOS记录号	WOS:000273984900005
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/141988]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Huo-Fei,Liu, Xiu-Dong,Zhang, Ying,et al. Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives[J]. journal of nanoscience and nanotechnology,2010,10(4):2304-2313.
APA	Zhou, Huo-Fei,Liu, Xiu-Dong,Zhang, Ying,&Ma, Xiao-Jun.(2010).Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives.journal of nanoscience and nanotechnology,10(4),2304-2313.
MLA	Zhou, Huo-Fei,et al."Preparation and Characterization of Nanoaggregates Self-Assembled by Lithocholic Acid and N-Trimethyl Modified Chitosan Derivatives".journal of nanoscience and nanotechnology 10.4(2010):2304-2313.