C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes

	C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes
	Zhang, Y. -Y.1,3; Liu, Y.1; Zhang, J. -W.1; Ge, G. -B.1; Liu, H. -X.1,3; Wang, L. -M.2; Sun, J.2; Yang, L.1
刊名	xenobiotica
	2009-12-01
卷号	39 期号:12 页码:903-914
关键词	7-Epi-cephalomannine 7-epi-10-deacetyl-paclitaxel paclitaxel cytochrome P450 structure-metabolism relationships metabolism
英文摘要	1. taxanes exhibit a high tendency to epimerize at c-7 under physiological conditions. this study aimed to investigate the composite effect of c-7 configuration and other substructural elements on the metabolic properties of taxanes. cephalomannine, 7-epi-cephalomannine, 10-deacetyl-paclitaxel, and 7-epi-10-deacetyl-paclitaxel were chosen as model compounds.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	pharmacology & pharmacy ; toxicology
研究领域[WOS]	pharmacology & pharmacy ; toxicology
关键词[WOS]	ionization mass-spectrometry ; in-vitro metabolism ; liver-microsomes ; paclitaxel pharmacokinetics ; regioselective metabolism ; cyclophosphamide ; degradation ; specificity ; docetaxel ; substrate
收录类别	SCI
语种	英语
WOS记录号	WOS:000272618900003
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/141444]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 2, Dalian, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Y. -Y.,Liu, Y.,Zhang, J. -W.,et al. C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes[J]. xenobiotica,2009,39(12):903-914.
APA	Zhang, Y. -Y..,Liu, Y..,Zhang, J. -W..,Ge, G. -B..,Liu, H. -X..,...&Yang, L..(2009).C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes.xenobiotica,39(12),903-914.
MLA	Zhang, Y. -Y.,et al."C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes".xenobiotica 39.12(2009):903-914.