Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy

	Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy
	Zhang, Z.1,2; Liu, S.1; Xiong, H.1,2; Jing, X.1; Xie, Z.1; Chen, X.3; Huang, Y.1
刊名	ACTA BIOMATERIALIA
	2015-10-15
卷号	26 页码:115-123
关键词	Electrospun nanofibers Doxorubicin MWCNTs Local treatment Combination cancer therapy
英文摘要	Carbon nanotubes are effective thermal generators by absorbing near-infrared radiation (NIR). In this study, multiwalled carbon nanotubes (MWCNTs) and doxorubicin (DOX) were successfully electrospun into the poly-I.-lactic acid (PLLA) nanofibers. It is confirmed that NIR radiation could not only initiate burst release of DOX from the fibers due to the relatively low glass transition temperature (T-g) of PLLA, but also significantly increase the temperature of fibers-covering tumor site. The multifunctional fibers showed increased cytotoxicity both in vitro and in vivo by the combination of photothermal induced hyperthermia and chemotherapy with DOX. This drug delivery system could be very useful and convenient in future clinical applications for localized cancer therapy.
收录类别	SCI
语种	英语
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28910]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Z.,Liu, S.,Xiong, H.,et al. Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy[J]. ACTA BIOMATERIALIA,2015,26:115-123.
APA	Zhang, Z..,Liu, S..,Xiong, H..,Jing, X..,Xie, Z..,...&Huang, Y..(2015).Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy.ACTA BIOMATERIALIA,26,115-123.
MLA	Zhang, Z.,et al."Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy".ACTA BIOMATERIALIA 26(2015):115-123.