Uniform PEGylated PLGA Microcapsules with Embedded Fe3O4 Nanoparticles for US/MR Dual-Modality Imaging

	Uniform PEGylated PLGA Microcapsules with Embedded Fe3O4 Nanoparticles for US/MR Dual-Modality Imaging
	Xu, Sijia 1; Yang, Fei 1; Zhou, Xiao 2; Zhuang, Yaping 1; Liu, Baoxia 1; Mu, Yang 2; Wang, Xing 1; Shen, Hong 1; Zhi, Guang 2; Wu, Decheng 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015-09-16
卷号	7 期号:36 页码:20460-20468
关键词	Fe3O4 nanoparticles PEG-PLGA microcapsules contrast agents ultrasound imaging magnetic resonance imaging
英文摘要	Well-designed agents for enhanced multimodal imaging have attracted great interests in recent years. In this work, we adopted a premix membrane emulsification (PME) method to prepare uniform PEGylated poly(lactic-co-glycolic acid) (PLGA) microcapsules (MCs) with superparamagnetic Fe3O4 nanoparticles (NPs) embedded in the shell (Fe3O4@PEG-PLGA MCs) for ultrasound (US)/magnetic resonance (MR) bimodal imaging. Compared to Fe3O4@PLGA MCs without PEGylation, Fe3O4@PEG-PLGA MCs could more stably and homogeneously disperse in physiological solutions. In vitro and in vivo trials demonstrated that Fe3O4@PEG-PLGA MCs (similar to 3.7 mu m) with very narrow size distribution (PDI = 0.03) could function as efficient dual-modality contrast agents to simultaneously enhance US and MR imaging performance greatly. In vitro cell toxicity and careful histological examinations illustrated no appreciable cytotoxicity and embolism of Fe3O4@ PEG-PLGA MCs to mice even at high dose. The uniform composite MCs developed here can act as clinical bimodal contrast agents to improve hybrid US/MR. imaging contrast, which is promising for accurate diagnosis and real-time monitoring of difficult and complicated diseases.
收录类别	SCI
语种	英语
公开日期	2015-11-03
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28369]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China
推荐引用方式 GB/T 7714	Xu, Sijia,Yang, Fei,Zhou, Xiao,et al. Uniform PEGylated PLGA Microcapsules with Embedded Fe3O4 Nanoparticles for US/MR Dual-Modality Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(36):20460-20468.
APA	Xu, Sijia.,Yang, Fei.,Zhou, Xiao.,Zhuang, Yaping.,Liu, Baoxia.,...&Wu, Decheng.(2015).Uniform PEGylated PLGA Microcapsules with Embedded Fe3O4 Nanoparticles for US/MR Dual-Modality Imaging.ACS APPLIED MATERIALS & INTERFACES,7(36),20460-20468.
MLA	Xu, Sijia,et al."Uniform PEGylated PLGA Microcapsules with Embedded Fe3O4 Nanoparticles for US/MR Dual-Modality Imaging".ACS APPLIED MATERIALS & INTERFACES 7.36(2015):20460-20468.