Homogeneous synthesis of amino-reserved chitosan-graft-polycaprolactone in an ionic liquid and the application in cell cultivation

	Homogeneous synthesis of amino-reserved chitosan-graft-polycaprolactone in an ionic liquid and the application in cell cultivation
	Yang, Lili 1,2; Zhang, Jinming 1; He, Jiasong 1; Zhang, Jun 1; Gan, Zhihua 3
刊名	POLYMER INTERNATIONAL
	2015-08-01
卷号	64 期号:8 页码:1045-1052
关键词	chitosan polycaprolactone aminosaccharide unit microsphere cell culture
英文摘要	The homogeneous preparation of amino-reserved chitosan-graft-polycaprolactone copolymer (ACS-g-PCL) was achieved in 1-butyl-3-methylimidazolium acetate via a protection - ring-opening graft polymerization - deprotection procedure. The molar substitution of PCL (MSPCL) in ACS-g-PCL copolymers was in the range 17.1 - 45.6 and could be well controlled by altering reaction conditions. The resultant ACS-g-PCL copolymers were soluble in some common organic solvents such as dimethylsulfoxide, ethanol and toluene. As the increment of MSPCL increased, the hydrophilicity of the ACS-g-PCL copolymers decreased. Eventually, ACS-g-PCL microspheres with a diameter of 100-200 mu m were fabricated by an emulsion evaporation method. Among them, the ACS-g-PCL copolymer with an MSPCL of 26.8 formed into porous microspheres. The fluorescence microscopy and cytotoxicity results suggested that all of the microspheres, especially the ACS-g-PCL microspheres with MSPCL of 17.1 and 26.8, showed high cell adhesion and cytocompatibility to the human osteosarcoma cell line (MG-63), indicating their great prospects in tissue engineering. (c) 2015 Society of Chemical Industry
收录类别	SCI
语种	英语
公开日期	2015-11-02
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/27909]
专题	化学研究所_工程塑料实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Engn Plast, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Organ Inorgan Composites, Beijing Lab Biomat, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Yang, Lili,Zhang, Jinming,He, Jiasong,et al. Homogeneous synthesis of amino-reserved chitosan-graft-polycaprolactone in an ionic liquid and the application in cell cultivation[J]. POLYMER INTERNATIONAL,2015,64(8):1045-1052.
APA	Yang, Lili,Zhang, Jinming,He, Jiasong,Zhang, Jun,&Gan, Zhihua.(2015).Homogeneous synthesis of amino-reserved chitosan-graft-polycaprolactone in an ionic liquid and the application in cell cultivation.POLYMER INTERNATIONAL,64(8),1045-1052.
MLA	Yang, Lili,et al."Homogeneous synthesis of amino-reserved chitosan-graft-polycaprolactone in an ionic liquid and the application in cell cultivation".POLYMER INTERNATIONAL 64.8(2015):1045-1052.