Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery

	Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery
	Lin, Wenhai 1,2; Guan, Xingang 1,3; Sun, Tingting 1,2; Huang, Yubin 1; Jing, Xiabing 1; Xie, Zhigang 1
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2015-02-01
卷号	126 页码:217-223
关键词	Multi-component Passerini reaction Reduction-sensitive Micelles Curcumin Drug delivery
英文摘要	One-step synthesis of amphiphilic polymers containing disulfide bond within the hydrophobic backbone was demonstrated via multi-component Passerini reaction. The obtained polymer was self-assembled into micelles in aqueous solution. Curcumin (CUR), an effective and safe anticancer agent, which was limited by its water insolubility and poor bioavailability, was loaded into the micelles as a model drug. The nanoscale polymeric micelles were confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Faster intracellular CUR release was observed by confocal laser scanning microscopy (CLSM) in the HeLa cells pretreated with GSH than in the unpretreated ones. Micelles also loaded with NH2-BODIPY which was almost non-fluorescent and gave strong enhanced fluorescence under acid conditions. The phenomenon of the stronger enhanced fluorescence in the pretreated HeLa cells showed further that the obtained polymer was reduction-sensitive. In vitro MTT assays showed that the micelles were biocompatible and CUR-loaded micelles had higher cellular proliferation inhibition in contrast to free CUR toward HeLa cells. These results highlight the potential of using multi-component Passerini reaction to make functional copolymers as smart nanocarriers for drug delivery. (C) 2014 Elsevier B.V. All rights reserved.
收录类别	SCI
语种	英语
公开日期	2015-11-02
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28287]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 10039, Peoples R China 3.Beihua Univ, Life Sci Res Ctr, Fengman 132013, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Lin, Wenhai,Guan, Xingang,Sun, Tingting,et al. Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2015,126:217-223.
APA	Lin, Wenhai,Guan, Xingang,Sun, Tingting,Huang, Yubin,Jing, Xiabing,&Xie, Zhigang.(2015).Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery.COLLOIDS AND SURFACES B-BIOINTERFACES,126,217-223.
MLA	Lin, Wenhai,et al."Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery".COLLOIDS AND SURFACES B-BIOINTERFACES 126(2015):217-223.