Cell Metabolomics Study of Hg (II) Ion Effect on the Metabolic Pathways of Cells

	Cell Metabolomics Study of Hg (II) Ion Effect on the Metabolic Pathways of Cells
	Zhang Ruixing ; Liu Shu ; Pi Zifeng ; Song,Fengrui ; Liu,Zhiqiang
刊名	高等学校化学学报 chemical journal of chinese universities-chinese
	2014
卷号	35 期号:6 页码:1146-1151
关键词	INDUCED OXIDATIVE STRESS HEAVY-METAL TOXICITY MASS-SPECTROMETRY MERCURY URINE RATS METABONOMICS RESISTANCE CANCER SERUM
通讯作者	song,fr
英文摘要	mercury is harmful for human that can cause many diseases. but how it causes the disease and if any protective response from cell metabolism happens remain unclear till now. in this work, we analyzed the metabolomics of hela cells treated with hg(ii) ion by ultra-performance liquid chromatography-high resolution mass spectrometry. totally 16 metabolites have been found to change significantly during hg(ii) ion treatment by the facility of orthogonal partial least squares discriminant analysis (opls-da). the results showed that hg() ion could impact many metabolic reactions including energy metabolism, phospholipid metabolism, fatty acid metabolism, amino acid metabolism and nucleic acid metabolism. but cells also had some stress reactions to protect themselves from hg(ii) ion damage.
收录类别	SCI
语种	英语
WOS记录号	WOS:000338273200005
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57541]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang Ruixing,Liu Shu,Pi Zifeng,et al. Cell Metabolomics Study of Hg (II) Ion Effect on the Metabolic Pathways of Cells[J]. 高等学校化学学报 chemical journal of chinese universities-chinese,2014,35(6):1146-1151.
APA	Zhang Ruixing,Liu Shu,Pi Zifeng,Song,Fengrui,&Liu,Zhiqiang.(2014).Cell Metabolomics Study of Hg (II) Ion Effect on the Metabolic Pathways of Cells.高等学校化学学报 chemical journal of chinese universities-chinese,35(6),1146-1151.
MLA	Zhang Ruixing,et al."Cell Metabolomics Study of Hg (II) Ion Effect on the Metabolic Pathways of Cells".高等学校化学学报 chemical journal of chinese universities-chinese 35.6(2014):1146-1151.