Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry

	Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry
	Hu, Yu ; Jin, Jing ; Han, Yuanyuan ; Yin,Jinghua ; Jiang,W ; Liang,Haojun
刊名	rsc advances
	2014
卷号	4 期号:15 页码:7716-7724
关键词	SELF-ASSEMBLED MONOLAYERS X-RAY REFLECTIVITY PROTEIN ADSORPTION QCM-D TITANIUM-OXIDE POLYMER-FILMS CHAIN DENSITY THIN-FILMS REAL-TIME GOLD
通讯作者	jiang,w
英文摘要	protein adsorption behavior is a key factor that determines whether materials can be used as medical polymer materials. in this study, fibrinogen (fib) adsorptions on three different poly(ethylene glycol) (peg) surfaces that differed in chain length and chain density were investigated using a quartz crystal microbalance with dissipation (qcm-d) and a dual polarization interferometry (dpi) with respect to adsorbed masses, viscoelastic properties and chain conformations. on qcm-d chips, peg chains were tight and in extended brush conformations. meanwhile, on dpi chips, peg(1000) and peg(2000) may have the same pancake-like conformations, but peg(5000) had a mushroom conformation. moreover, several bare spaces were observed on the loose pancake-like peg(1000)- and peg(2000)-modified dpi surfaces. fib could fully spread on the relatively dense peg(1000)-modified dpi surface and partly spread and tightly orient on the relatively sparse peg(2000)-modified dpi surface. thus, grafting density was found to have greater significance in determining fib adsorption resistance due to its influence on fib spreading when the chain conformations of hydrophilic molecules were loose pancake-like structures. furthermore, brush and mushroom structured peg(5000) chains both had high deformation capacity, which excellently resisted protein adsorption by adjusting their conformation to decrease interaction with fib. therefore, the fib adsorption resistance of peg-modified surface depended on the grafting density of peg layer and the deformation capacity of the peg chain.
收录类别	SCI
语种	英语
WOS记录号	WOS:000330241000052
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57251]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Hu, Yu,Jin, Jing,Han, Yuanyuan,et al. Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry[J]. rsc advances,2014,4(15):7716-7724.
APA	Hu, Yu,Jin, Jing,Han, Yuanyuan,Yin,Jinghua,Jiang,W,&Liang,Haojun.(2014).Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry.rsc advances,4(15),7716-7724.
MLA	Hu, Yu,et al."Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry".rsc advances 4.15(2014):7716-7724.