Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery

	Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery
	Gao, Xiaoye ; Cao, Yue ; Song, Xiangfu ; Zhang,Zhe ; Zhuang,Xiuli ; He,Chaoliang ; Chen,Xuesi
刊名	macromolecular bioscience
	2014
卷号	14 期号:4 页码:565-575
关键词	DRUG-DELIVERY COMPLEXATION HYDROGELS ENZYMATIC DEGRADATION SENSITIVE HYDROGEL CELLULOSE CHITOSAN RELEASE NETWORK GROWTH MICROPARTICLES
通讯作者	he,cl
英文摘要	biodegradable and ph-responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synthesized. the hydrogels deswell in acidic artificial gastric fluid (agf) but rapidly swell in neutral artificial intestinal fluid (aif), rendering selective enzymatic degradation of the gels as well as accelerated drug release from insulin-loaded hydrogels in aif. oral administration of insulin-loaded hydrogels to streptozotocin-induced diabetic rats leads to a continuous decline in the fasting blood glucose level within 6h post-administration, and the relative pharmacological availability increases more than 10 times compared to oral administration of free insulin solution. the relative bioavailability of hydrogel-encapsulated insulin after oral administration to healthy rabbits is 6.6%.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57241]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Gao, Xiaoye,Cao, Yue,Song, Xiangfu,et al. Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery[J]. macromolecular bioscience,2014,14(4):565-575.
APA	Gao, Xiaoye.,Cao, Yue.,Song, Xiangfu.,Zhang,Zhe.,Zhuang,Xiuli.,...&Chen,Xuesi.(2014).Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery.macromolecular bioscience,14(4),565-575.
MLA	Gao, Xiaoye,et al."Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery".macromolecular bioscience 14.4(2014):565-575.