Proliferating resident microglia after focal cerebral ischaemia in mice

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Proliferating resident microglia after focal cerebral ischaemia in mice
	Denes, Adam ; Vidyasagar, Rishma ; Feng, Jianghua ; Narvainen, Johanna ; McColl, Barry W.; Kauppinen, Risto A.; Allan, Stuart M.
刊名	JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
	2007-12-01
卷号	27 期号:12 页码:1941-1953
关键词	cell labelling inflammation MRI macrophages neurodegeneration
英文摘要	Cerebral ischaemia usually results in the rapid death of neurons within the immediate territory of the affected artery. Neuronal loss is accompanied by a sequence of events, including brain oedema, blood-brain barrier (BBB) breakdown, and neuroinflammation, all of which contribute to further neuronal death. Although the role of macrophages and mononuclear phagocytes in the expansion of ischaemic injury has been widely studied, the relative contribution of these cells, either of exogenous or intrinsic central nervous system (CNS) origin is still not entirely clear. The purpose of this study, therefore, was to use different durations of transient middle cerebral artery occlusion (tMCAo) in the mouse to investigate fully post-occlusion BBB permeability and cellular changes in the brain during the 72 h post-MCAo period. This was achieved using in vivo magnetic resonance imaging (MRI) and cell labelling techniques. Our results show that BBB breakdown and formation of the primary ischaemic damage after tMCAo is not associated with significant infiltration of neutrophils, although more are observed with longer periods of MCAo. In addition, we observe very few infiltrating exogenous macrophages over a 72 h period after 30 or 60 mins of occlusion, instead a profound increase in proliferating resident microglia cells was observed. Interestingly, the more severe injury associated with 60 mins of MCAo leads to a markedly reduced proliferation of resident microglial cells, suggesting that these cells may play a protective function, possibly through phagocytosis of infiltrating neutrophils. These data further support possible beneficial actions of microglial cells in the injured brain.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Endocrinology & Metabolism ; Hematology ; Neurosciences
研究领域[WOS]	Endocrinology & Metabolism ; Hematology ; Neurosciences & Neurology
关键词[WOS]	MARROW CHIMERIC MICE ; BONE-MARROW ; RAT-BRAIN ; ARTERY OCCLUSION ; HEMATOGENOUS MACROPHAGES ; INFLAMMATORY RESPONSE ; GENE-EXPRESSION ; TISSUE-DAMAGE ; STROKE ; CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000250957800006
公开日期	2015-10-13
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/7916]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Hungarian Acad Sci, Inst Expt Med, Lab Mol Neuroendocrinol, H-1083 Budapest, Hungary 2.Univ Birmingham, Sch Sport & Exercise Sci, Birmingham, W Midlands, England 3.Univ Manchester, Fac Life Sci, Michael Smith Bldg, Manchester, Lancs, England 4.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Denes, Adam,Vidyasagar, Rishma,Feng, Jianghua,et al. Proliferating resident microglia after focal cerebral ischaemia in mice[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2007,27(12):1941-1953.
APA	Denes, Adam.,Vidyasagar, Rishma.,Feng, Jianghua.,Narvainen, Johanna.,McColl, Barry W..,...&Allan, Stuart M..(2007).Proliferating resident microglia after focal cerebral ischaemia in mice.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,27(12),1941-1953.
MLA	Denes, Adam,et al."Proliferating resident microglia after focal cerebral ischaemia in mice".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 27.12(2007):1941-1953.