Molecular regulation of interferon antiviral response in fish

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	Molecular regulation of interferon antiviral response in fish
	Zhang, Yi-Bing; Gui, Jian-Fang
刊名	DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
	2012-10-01
卷号	38 期号:2 页码:193-202
关键词	Fish IFN antiviral response Jak-Stat signaling pathway TLR pathway RLR pathway Auto-regulation Molecular regulation
ISSN号	0145-305X
英文摘要	Interferon (IFN) response is the first line of host defense against virus infection. The recent years have witnessed tremendous progress in understanding of fish IFN antiviral response. Varied number of IFN genes has been identified in different fish species but obviously, they do not show a one-to-one orthologous relationship with mammalian IFN homologs. These genes are divided into two groups with different abilities to induce downstream gene expression through binding to different receptor complexes. Consistently, some fish IFN-stimulated genes such as Mx and PKR have been confirmed for their antiviral effects. In this review, we focus on how fish cells respond to IFNs and how fish IFNs are triggered through TLR pathway and RLR pathway. We highlight the roles of IRF3 and IRF7 in activation of fish IFN response. In addition, the unique mechanisms underlying IRF3/7-dependent fish IFN response and auto-regulation of fish IFN gene expression are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Immunology ; Zoology
研究领域[WOS]	Immunology ; Zoology
关键词[WOS]	SALMON SALMO-SALAR ; INNATE IMMUNE-RESPONSE ; TOLL-LIKE RECEPTORS ; PANCREATIC NECROSIS VIRUS ; TROUT ONCORHYNCHUS-MYKISS ; DEPENDENT PROTEIN-KINASE ; ZEBRAFISH DANIO-RERIO ; UV-INACTIVATED VIRUS ; DNA BINDING DOMAINS ; NF-KAPPA-B
收录类别	SCI
语种	英语
WOS记录号	WOS:000309312700001
公开日期	2015-10-06
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/27125]
专题	水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
作者单位	Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yi-Bing,Gui, Jian-Fang. Molecular regulation of interferon antiviral response in fish[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2012,38(2):193-202.
APA	Zhang, Yi-Bing,&Gui, Jian-Fang.(2012).Molecular regulation of interferon antiviral response in fish.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,38(2),193-202.
MLA	Zhang, Yi-Bing,et al."Molecular regulation of interferon antiviral response in fish".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 38.2(2012):193-202.