Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos | |
Liu, Chunsheng2,3; Yan, Wei4; Zhou, Bingsheng5; Guo, Yongyong5; Liu, Hongling2,3; Yu, Hongxia2,3; Giesy, John P.6,7,8,9; Wang, Jianghua1; Li, Guangyu1,5; Zhang, Xiaowei2,3 | |
刊名 | AQUATIC TOXICOLOGY
![]() |
2012-08-15 | |
卷号 | 118页码:108-115 |
关键词 | Melanin synthesis Microinjection Bystander exposure Risk assessment |
ISSN号 | 0166-445X |
英文摘要 | This study was conducted to evaluate possible bystander effects induced by the model chemical 6-propyl-2-thiouracil (PTU) on melanin synthesis. Zebrafish (Danio rerio) embryos were treated with PTU by either microinjection exposure, via waterborne exposure or indirectly through bystander exposure. Melanin content, related mRNA and protein expression were examined at the end of exposure (36 h post-fertilization). Direct exposure to FLU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (7YR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV. Bystander exposure also up-regulated mRNA and protein expressions of TYR and SILV but increased melanin contents. Correlation analysis demonstrated that mRNA expressions of OCA2, TYR, DCT, TYRP1, SILV and protein expressions of TYR and SILV in bystander exposure groups were positively correlated with corresponding expressions in microinjection exposure groups. The results might have environmental implications and highlight the need to consider the bystander effects when assessing potential risks of endocrine-disrupting chemicals. (C) 2012 Elsevier B.V. All rights reserved. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Marine & Freshwater Biology ; Toxicology |
研究领域[WOS] | Marine & Freshwater Biology ; Toxicology |
关键词[WOS] | RADIATION-INDUCED STRESS ; PITUITARY-GONADAL AXIS ; MEDAKA ORYZIAS-LATIPES ; COMMUNICATED IN-VIVO ; RAINBOW-TROUT ; GENE-EXPRESSION ; POMATOSCHISTUS-MINUTUS ; FISH BEHAVIOR ; SAND GOBY ; PCR ARRAY |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000305102400012 |
公开日期 | 2015-10-06 |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/27130] ![]() |
专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
作者单位 | 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China 2.Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Nanjing 210093, Peoples R China 3.Nanjing Univ, Sch Environm, Nanjing 210093, Peoples R China 4.Hubei Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Wuhan 430064, Hubei, Peoples R China 5.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China 6.Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK, Canada 7.Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK, Canada 8.City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China 9.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Chunsheng,Yan, Wei,Zhou, Bingsheng,et al. Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos[J]. AQUATIC TOXICOLOGY,2012,118:108-115. |
APA | Liu, Chunsheng.,Yan, Wei.,Zhou, Bingsheng.,Guo, Yongyong.,Liu, Hongling.,...&Zhang, Xiaowei.(2012).Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos.AQUATIC TOXICOLOGY,118,108-115. |
MLA | Liu, Chunsheng,et al."Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos".AQUATIC TOXICOLOGY 118(2012):108-115. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论