Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 水生生物多样性与资源保护研究中心 > 期刊论文

	Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii
	Chi, Wei; Gan, Xiaoni; Xiao, Wuhan; Wang, Wen; He, Shunping
刊名	FEBS OPEN BIO
	2013
卷号	3 页码:479-483
关键词	HIF-alpha Osteichthyes Functional divergence Positive selection
ISSN号	2211-5463
英文摘要	Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-alpha isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-alpha isoforms in different lineages. Only the HIF-1 alpha and HIF-2 alpha in African lungfish and amphibians were found under positive selection. HIF-1 alpha and -2 alpha were less functionally divergent in basal ray-finned fish than in teleosts, and showed conserved but different transcriptional activity towards specific target genes. (C) 2013 The Authors, Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies. All rights reserved.
关键词[WOS]	FUNCTIONAL DIVERGENCE ; ATMOSPHERIC OXYGEN ; HIGH-ALTITUDE ; FACTOR-1-ALPHA ; HIF-2-ALPHA ; HOMEOSTASIS ; ADAPTATION ; REGULATOR ; DOMAINS ; PATHWAY
收录类别	SCI
语种	英语
WOS记录号	WOS:000339569800075
公开日期	2015-09-29
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/27117]
专题	水生生物研究所_水生生物多样性与资源保护研究中心_期刊论文
作者单位	Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Chi, Wei,Gan, Xiaoni,Xiao, Wuhan,et al. Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii[J]. FEBS OPEN BIO,2013,3:479-483.
APA	Chi, Wei,Gan, Xiaoni,Xiao, Wuhan,Wang, Wen,&He, Shunping.(2013).Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii.FEBS OPEN BIO,3,479-483.
MLA	Chi, Wei,et al."Different evolutionary patterns of hypoxia-inducible factor alpha (HIF-alpha) isoforms in the basal branches of Actinopterygii and Sarcopterygii".FEBS OPEN BIO 3(2013):479-483.