Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study

CORC > 自动化研究所 > 中国科学院自动化研究所 > 复杂系统管理与控制国家重点实验室 > 先进控制与自动化团队

	Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study
	Eckert, Ulf ; Metzger, Coraline D.; Buchmann, Julia E.; Kaufmann, Joern 2; Osoba, Annemarie ; Li, Meng4 ; Safron, Adam 5; Liao, Wei 3; Steiner, Johann ; Bogerts, Bernhard
刊名	HUMAN BRAIN MAPPING
	2012-11-01
卷号	33 期号:11 页码:2627-2637
关键词	mediodorsal thalamus centromedian thalamus cortical networks subcortical network diffusion tensor imaging (DTI) quantitative tractography structural connectivity human neuroanatomy deep brain stimulation
英文摘要	Distinct thalamic nuclei, like the mediodorsal (MD) nucleus and the centromedian/parafascicular complex (CM/Pf), are embedded in different basal gangliathalamocortical loops, which were shown to integrate cognitive and emotional aspects of human behavior. Despite well described connections on a microscopic scale, derived from tracing studies in animals, little is known about the intrinsic anatomical connections of these nuclei in humans. This lack of knowledge limits not only interpretation of functional imaging studies but also estimation of direct effects of deep brain stimulation which treats diseases as different as epilepsy or major depression. Therefore, non-invasive diffusion tensor imaging (DTI) studies are key to analyzing connectivity patterns and elaborate approaches to close this gap. For our study, we explored the structural connectivity of the MD thalamic nuclei and the CM/Pf complex towards five cortical and six subcortical regions by using a preferential fiber calculation. We found both thalamic nuclei to be preferentially associated to distinct networks: whereas the MD is preferentially connected to prefrontal and limbic cortical regions, the CM is linked to subcortical regions. The anterior insula was the only cortical region associated with the subcortical network of the CM and the cortical network of the MD comprised one subcortical hub, the caudate nucleus, suggesting an integrative role of these two regions. Adding to predescribed anatomical tract tracing connectivities in animal studies, our finding lends support to the existence of similar basal ganglia-thalamocortical circuits in humans and we could show a robust distinction of preferential connectivity for both thalamic nuclei. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]	MEDIAL PREFRONTAL CORTEX ; DEEP BRAIN-STIMULATION ; CM-PF COMPLEX ; BASAL GANGLIA ; CINGULATE CORTEX ; RHESUS-MONKEY ; AFFERENT CONNECTIONS ; THEORETICAL-ANALYSIS ; INTRALAMINAR NUCLEI ; MACAQUE MONKEYS
收录类别	SCI
语种	英语
WOS记录号	WOS:000310264500010
公开日期	2015-09-22
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/8011]
专题	自动化研究所_复杂系统管理与控制国家重点实验室_先进控制与自动化团队
作者单位	1.Univ Magdeburg, Dept Psychiat, Clin Affect Neuroimaging Lab, D-39120 Magdeburg, Germany 2.Otto von Guericke Univ, Dept Neurol, Magdeburg, Germany 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 4.Chinese Acad Sci, Inst Automat, Key Lab Complex Syst & Intelligence Sci, Beijing 100864, Peoples R China 5.Northwestern Univ, Dept Psychol, Evaston, IL USA
推荐引用方式 GB/T 7714	Eckert, Ulf,Metzger, Coraline D.,Buchmann, Julia E.,et al. Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study[J]. HUMAN BRAIN MAPPING,2012,33(11):2627-2637.
APA	Eckert, Ulf.,Metzger, Coraline D..,Buchmann, Julia E..,Kaufmann, Joern.,Osoba, Annemarie.,...&Walter, Martin.(2012).Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study.HUMAN BRAIN MAPPING,33(11),2627-2637.
MLA	Eckert, Ulf,et al."Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study".HUMAN BRAIN MAPPING 33.11(2012):2627-2637.