Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)

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	Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)
	Xiao, Zhangang 1,2; Shen, Jing 2; Feng, Hong 1; Liu, Hong 3; Wang, Yaping 1; Huang, Rong 1; Guo, Qionglin 1
刊名	DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
	2015-05-01
卷号	50 期号:1 页码:29-37
关键词	prothymosin alpha (ProT alpha) beta thymosin (T beta) Common carp Spring viraemia of carp virus (SVCV)
ISSN号	0145-305X
通讯作者	Xiao, ZG (reprint author), Chinese Univ Hong Kong, Lo Kwee Seong Integrated Biomed Sci Bldg,Rm 507, Hong Kong, Hong Kong, Peoples R China.
英文摘要	Prothymosin alpha (ProT alpha) and thymosin beta (T beta) belong to thymosin family, which consists of a series of highly conserved peptides involved in stimulating immune responses. ProT alpha b and T beta are still poorly studied in teleost. Here, the full-length cDNAs of ProT alpha b and T beta-like (T beta-l) were cloned and identified in common carp (Cyprinus carpi L). The expressions of carp ProT alpha b and T beta-l exhibited rise-fall pattern and then trended to be stable during early development. After spring viraemia of carp virus (SVCV) infection, the carp ProT alpha b and T beta-l transcripts were significantly up-regulated in some immune-related organs. When transiently over-expressed carp ProT alpha b and T beta-l in zebrafish, these two proteins upregulated the expressions of T lymphocytes-related genes (Rag 1, TCR-gamma, CD4 and CD8 alpha). These results suggest that carp ProT alpha b and T beta may ultimately enhance the immune response during viral infection and modulate the development of T lymphocytes in teleost. (C) 2015 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Immunology ; Zoology
研究领域[WOS]	Immunology ; Zoology
关键词[WOS]	HUMAN PROTHYMOSIN-ALPHA ; DIFFERENTIAL EXPRESSION ; SPRING VIREMIA ; BETA-THYMOSINS ; MESSENGER-RNA ; RAT-TISSUES ; VIRUS SVCV ; IN-VITRO ; IDENTIFICATION ; CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000350931900005
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/23903]
专题	水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China 2.Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China 3.Shenzhen Exit & Entry Inspect & Quarantine Bur, Key Lab Aquat Anim Dis, Shenzhen 518001, Peoples R China
推荐引用方式 GB/T 7714	Xiao, Zhangang,Shen, Jing,Feng, Hong,et al. Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2015,50(1):29-37.
APA	Xiao, Zhangang.,Shen, Jing.,Feng, Hong.,Liu, Hong.,Wang, Yaping.,...&Guo, Qionglin.(2015).Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.).DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,50(1),29-37.
MLA	Xiao, Zhangang,et al."Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 50.1(2015):29-37.