DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy

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	DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy
	Zhang, Qian1,2,3 ; Jiang, Qiao 4; Li, Na 4; Dai, Luru 4; Liu, Qing 4; Song, Linlin 4; Wang, Jinye 4; Li, Yaqian 3; Tian, Jie1,2,3 ; Ding, Baoquan 4
刊名	ACS NANO
	2014-07-01
卷号	8 期号:7 页码:6633-6643
关键词	DNA origami doxorubicin in vivo delivery cancer therapy fluorescence imaging
英文摘要	Many chemotherapeutics used for cancer treatments encounter issues during delivery to tumors in vivo and may have high levels of systemic toxicity due to their nonspecific distribution. Various materials have been explored to fabricate nanoparticles as drug carriers to Improve delivery efficiency. However, most of these materials suffer from multiple drawbacks, such as limited biocompatibility and inability to engineer spatially addressable surfaces that can be utilized for multifunctional activity. Here, we demonstrate that DNA origami possessed enhanced tumor passive targeting and long-lasting properties at the tumor region. Particularly, the triangle-shaped DNA origami exhibits optimal tumor passive targeting accumulation. The delivery of the known anticancer drug doxorubicin into tumors by self-assembled DNA origami nanostructures was performed, and this approach showed prominent therapeutic efficacy in vivo. The DNA origami carriers were prepared through the self-assembly of M13mp18 phage DNA and hundreds of complementary DNA helper strands; the doxorubicin was subsequently noncovalently intercalated into these nanostructures. After conducting fluorescence imaging and safety evaluation, the doxorubicin-containing DNA origami exhibited remarkable antitumor efficacy without observable systemic toxicity in nude mice bearing orthotopic breast tumors labeled with green fluorescent protein. Our results demonstrated the potential of DNA origami nanostructures as innovative platforms for the efficient and safe drug delivery of cancer therapeutics in vivo.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]	NANOPARTICLES ; DOXORUBICIN ; NANOTECHNOLOGY ; CHEMOTHERAPY ; RATS ; NANOSTRUCTURES ; CHALLENGES ; LIPOSOMES ; DISCOVERY ; IMPROVES
收录类别	SCI
语种	英语
WOS记录号	WOS:000339463100017
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/4021]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Natl Ctr NanoSci & Technol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Qian,Jiang, Qiao,Li, Na,et al. DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy[J]. ACS NANO,2014,8(7):6633-6643.
APA	Zhang, Qian.,Jiang, Qiao.,Li, Na.,Dai, Luru.,Liu, Qing.,...&Du, Yang.(2014).DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy.ACS NANO,8(7),6633-6643.
MLA	Zhang, Qian,et al."DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy".ACS NANO 8.7(2014):6633-6643.