Acupuncture Induces Divergent Alterations of Functional Connectivity within Conventional Frequency Bands: Evidence from MEG Recordings

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	Acupuncture Induces Divergent Alterations of Functional Connectivity within Conventional Frequency Bands: Evidence from MEG Recordings
	You, Youbo 1; Bai, Lijun 1; Dai, Ruwei1 ; Zhong, Chongguang 1; Xue, Ting 2; Wang, Hu 1; Liu, Zhenyu1 ; Wei, Wenjuan 1; Tian, Jie1,2
刊名	PLOS ONE
	2012-11-09
卷号	7 期号:11 页码:-
英文摘要	As an ancient Chinese healing modality which has gained increasing popularity in modern society, acupuncture involves stimulation with fine needles inserted into acupoints. Both traditional literature and clinical data indicated that modulation effects largely depend on specific designated acupoints. However, scientific representations of acupoint specificity remain controversial. In the present study, considering the new findings on the sustained effects of acupuncture and its time-varied temporal characteristics, we employed an electrophysiological imaging modality namely magnetoencephalography with a temporal resolution on the order of milliseconds. Taken into account the differential band-limited signal modulations induced by acupuncture, we sought to explore whether or not stimulation at Stomach Meridian 36 (ST36) and a nearby non-meridian point (NAP) would evoke divergent functional connectivity alterations within delta, theta, alpha, beta and gamma bands. Whole-head scanning was performed on 28 healthy participants during an eyes-closed no-task condition both preceding and following acupuncture. Data analysis involved calculation of band-limited power (BLP) followed by pair-wise BLP correlations. Further averaging was conducted to obtain local and remote connectivity. Statistical analyses revealed the increased connection degree of the left temporal cortex within delta (0.5-4 Hz), beta (13-30 Hz) and gamma (30-48 Hz) bands following verum acupuncture. Moreover, we not only validated the closer linkage of the left temporal cortex with the prefrontal and frontal cortices, but further pinpointed that such patterns were more extensively distributed in the ST36 group in the delta and beta bands compared to the restriction only to the delta band for NAP. Psychophysical results for significant pain threshold elevation further confirmed the analgesic effect of acupuncture at ST36. In conclusion, our findings may provide a new perspective to lend support for the specificity of neural expression underlying acupuncture.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	FALSE DISCOVERY RATE ; PARKINSONS-DISEASE ; HUMAN BRAIN ; PHASE SYNCHRONIZATION ; SENSORY STIMULATION ; ALZHEIMERS-DISEASE ; FMRI ; ELECTROACUPUNCTURE ; MODULATION ; ACUPOINTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000312272600054
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/4015]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Intelligent Med Res Ctr, Inst Automat, Beijing, Peoples R China 2.Xidian Univ, Sch Elect Engn, Life Sci Res Ctr, Xian, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	You, Youbo,Bai, Lijun,Dai, Ruwei,et al. Acupuncture Induces Divergent Alterations of Functional Connectivity within Conventional Frequency Bands: Evidence from MEG Recordings[J]. PLOS ONE,2012,7(11):-.
APA	You, Youbo.,Bai, Lijun.,Dai, Ruwei.,Zhong, Chongguang.,Xue, Ting.,...&Tian, Jie.(2012).Acupuncture Induces Divergent Alterations of Functional Connectivity within Conventional Frequency Bands: Evidence from MEG Recordings.PLOS ONE,7(11),-.
MLA	You, Youbo,et al."Acupuncture Induces Divergent Alterations of Functional Connectivity within Conventional Frequency Bands: Evidence from MEG Recordings".PLOS ONE 7.11(2012):-.