Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation
	Hu, Zhenhua1 ; Liang, Jimin 1; Yang, Weidong 2; Fan, Weiwei 3; Li, Congye 3; Ma, Xiaowei 2; Chen, Xueli 1; Ma, Xiaopeng 1; Li, Xiangsi 1; Qu, Xiaochao 1
刊名	OPTICS EXPRESS
	2010-11-22
卷号	18 期号:24 页码:24441-24450
英文摘要	Optical molecular imaging resulting from Cerenkov radiation has become a motivating topic recently and will potentially open new avenues for the study of small animal imaging. Cerenkov-based optical imaging taken from living animals in vivo has been studied with two-dimensional (2D) planar geometry and three-dimensional (3D) homogeneous mouse model. In this study, we performed 3D Cerenkov-based luminescence tomography (CLT) using a heterogeneous mouse model with an implanted Na(131)I radioactive source, which provided the accurate location for the reconstructed source. Furthermore, single photon emission computed tomography (SPECT) was utilized to verify the results of 3D CLT. We reconstructed the localization and intensity of an embedded radioactive source with various concentrations, and established a quantitative relationship between the radiotracer activity and the reconstructed intensity. The results showed the ability of in vivo CLT to recover the radioactive probe distribution in the heterogeneous mouse model and the potential of a SPECT imaging validation strategy to verify the results of optical molecular tomography. (C) 2010 Optical Society of America
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Optics
研究领域[WOS]	Optics
关键词[WOS]	POSITRON-EMITTING RADIOTRACERS ; FINITE-ELEMENT ALGORITHM ; BIOLUMINESCENCE TOMOGRAPHY ; FLUORESCENCE TOMOGRAPHY ; RECONSTRUCTION ; LIGHT ; RADIATION ; SYSTEM
收录类别	SCI
语种	英语
WOS记录号	WOS:000285586800058
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3934]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian 710071, Peoples R China 2.Fourth Mil Med Univ, Dept Nucl Med, Xijing Hosp, Xian 710032, Peoples R China 3.Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Hu, Zhenhua,Liang, Jimin,Yang, Weidong,et al. Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation[J]. OPTICS EXPRESS,2010,18(24):24441-24450.
APA	Hu, Zhenhua.,Liang, Jimin.,Yang, Weidong.,Fan, Weiwei.,Li, Congye.,...&Tian, Jie.(2010).Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation.OPTICS EXPRESS,18(24),24441-24450.
MLA	Hu, Zhenhua,et al."Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation".OPTICS EXPRESS 18.24(2010):24441-24450.