Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease

	Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease
	Xu, Cunlu 1,2; Wang, Zhenhua 1,2; Fan, Ming 1; Liu, Bing1 ; Song, Ming1 ; Zhen, Xiantong 2; Jiang, Tianzi1 ; Alzheimers Dis Neuroimaging Initia
刊名	NEUROREPORT
	2010-08-23
卷号	21 期号:12 页码:802-807
关键词	Alzheimer's disease brain-derived neurotrophic factor cerebral metabolic rate for glucose polymorphism positron emission tomography
英文摘要	Earlier studies showed that the Val66Met polymorphisms of the brain-derived neurotrophic factor differentially affect gray matter volume and brain region activities. This study used resting positron emission tomography to investigate the relationship between the polymorphisms of Val66Met and the regional cerebral metabolic rate in the brain. We analyzed the positron emission tomography images of 215 patients from the Alzheimer's Disease Neuroimaging Initiative and found significant differences in the parahippocampal gyrus, superior temporal gyrus, prefrontal cortex, and inferior parietal lobule when comparing Met carriers with noncarriers among both the normal controls and those with mild cognitive impairment. For those with Alzheimer's disease, we also found additional differences in the bilateral insula between the carriers and noncarriers. NeuroReport 21:802-807 (C) 2010 Wolters Kluwer Health \| Lippincott Williams & Wilkins.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	NEUROTROPHIC FACTOR ; HIPPOCAMPAL ACTIVITY ; DEMENTIA ; INSULA ; VOLUME ; GENE ; MRI ; AGE
收录类别	SCI
语种	英语
WOS记录号	WOS:000280592900002
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3116]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 2.Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Xu, Cunlu,Wang, Zhenhua,Fan, Ming,et al. Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease[J]. NEUROREPORT,2010,21(12):802-807.
APA	Xu, Cunlu.,Wang, Zhenhua.,Fan, Ming.,Liu, Bing.,Song, Ming.,...&Alzheimers Dis Neuroimaging Initia.(2010).Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.NEUROREPORT,21(12),802-807.
MLA	Xu, Cunlu,et al."Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease".NEUROREPORT 21.12(2010):802-807.