Cortical thickness analysis and optimized voxel-based morphometry in children and adolescents with prelingually profound sensorineural hearing loss

CORC > 自动化研究所 > 中国科学院自动化研究所 > 复杂系统管理与控制国家重点实验室 > 影像分析与机器视觉团队

	Cortical thickness analysis and optimized voxel-based morphometry in children and adolescents with prelingually profound sensorineural hearing loss
	Li, Jianhong 1; Li, Wenjing 2; Xian, Junfang 1; Li, Yong 1; Liu, Zhaohui 1; Liu, Sha 3; Wang, Xiaocui 3; Wang, Zhenchang 1; He, Huiguang2
刊名	BRAIN RESEARCH
	2012-01-09
卷号	1430 页码:35-42
关键词	Children and adolescents Neuroplasticity Sensorineural hearing loss Cortical thickness Optimized voxel-based morphomety
英文摘要	Crossmodal neuroplastic changes following auditory deprivation in individuals with profound sensorineural hearing loss (SNHL) have been well documented in previous literature. However, previous studies have shown very little evidence of structural brain changes in individuals with prelingually profound SNHL and no studies have reported significant differences of gray matter (GM) in deaf subjects. Therefore, it is essential to employ a more specific and sensitive technique to detect subtle structural brain differences in deaf individuals. The objective of our study was to investigate neuroanatomical differences in children and adolescents with profound SNHL by cortical thickness analysis and optimized voxel-based morphometry (VBM). T1-weighted volumetric images of 16 children and adolescents with prelingually profound SNHL and 16 hearing controls were analyzed. The ANCOVA analysis revealed a statistically significant decreased average cortical thickness of the whole brain. As to vertex-based analysis, cortical thickness of the deaf subjects showed significant thinning in the left precentral gyms, right postcentral gyms, the left superior occipital gyrus and the left fusiform gyrus compared with the hearing subjects. VBM revealed statistically significant focal reduction of white matter (WM) volume in the left middle frontal gyms and the right inferior occipital gyrus in deaf subjects without statistically significant differences in GM volume between the two groups. These findings demonstrated that structural changes happened not only in the WM but also in the GM of the subjects with prelingually profound SNHL, which have never been reported before in any previous literature. Our results also implicated the potential neuroplastic changes associated with crossmodal reorganization in the brain after auditory deprivation in the early deafness. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	AUTOMATED 3-D EXTRACTION ; AUDITORY-CORTEX ; SIGN-LANGUAGE ; BRAIN-REGIONS ; COCHLEAR IMPLANTS ; MRI DATA ; DEAF ; DYSLEXIA ; CHINESE ; REGISTRATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000300534000005
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3740]
专题	自动化研究所_复杂系统管理与控制国家重点实验室_影像分析与机器视觉团队
作者单位	1.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing 100730, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Complex Syst & Intelligence Sci, Beijing 100190, Peoples R China 3.Capital Med Univ, Beijing Tongren Hosp, Beijing Inst Otolaryngol, Beijing 100005, Peoples R China
推荐引用方式 GB/T 7714	Li, Jianhong,Li, Wenjing,Xian, Junfang,et al. Cortical thickness analysis and optimized voxel-based morphometry in children and adolescents with prelingually profound sensorineural hearing loss[J]. BRAIN RESEARCH,2012,1430:35-42.
APA	Li, Jianhong.,Li, Wenjing.,Xian, Junfang.,Li, Yong.,Liu, Zhaohui.,...&He, Huiguang.(2012).Cortical thickness analysis and optimized voxel-based morphometry in children and adolescents with prelingually profound sensorineural hearing loss.BRAIN RESEARCH,1430,35-42.
MLA	Li, Jianhong,et al."Cortical thickness analysis and optimized voxel-based morphometry in children and adolescents with prelingually profound sensorineural hearing loss".BRAIN RESEARCH 1430(2012):35-42.