Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice

	Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice
	Ma, YH; Hu, JH; Zhao, WJ; Fei, J; Yu, Y; Zhou, XG; Mei, ZT; Guo, LH
刊名	CELL RESEARCH
	2001
卷号	11 期号:1 页码:61-67
关键词	gamma-aminobutyric acid transporter seizure susceptibility kainic acid electroencephalography transgenic mice
通讯作者	Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,
英文摘要	gamma -aminobutyric acid (GABA) is the principal inhibitory neurotransmitter, and the GABAergic synaptic transmission is normally terminated by the rapid uptake through GABA transporters. With transgenic mice ubiquitously overexpressing GABA transporter subtype I (GAT1), the present study explored the pathophysiological role of GAT1 in epileptogenesis. Though displaying no spontaneous seizure activity, these mice exhibit altered electroencephalographic patterns and increased susceptibility to seizure induced by kainic acid. In addition, the GABA(A) receptor and glutamate transporters are up-regulated in transgenic mice, which perhaps reflects a compensatory or corrective change to the elevated level of GAT1. These preliminary findings support the hypothesis that excitatory and inhibitory neurotransmission, and seizure susceptibility can be altered by neurotransmitter transporters.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	TEMPORAL-LOBE EPILEPSY ; GABA(A) RECEPTOR ; HIPPOCAMPAL GABA ; RAT ; EXPRESSION ; LACKING ; SUBUNIT ; RELEASE ; PRONE
收录类别	SCI
语种	英语
WOS记录号	WOS:000167901800008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2579]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ma, YH,Hu, JH,Zhao, WJ,et al. Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice[J]. CELL RESEARCH,2001,11(1):61-67.
APA	Ma, YH.,Hu, JH.,Zhao, WJ.,Fei, J.,Yu, Y.,...&Guo, LH.(2001).Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice.CELL RESEARCH,11(1),61-67.
MLA	Ma, YH,et al."Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice".CELL RESEARCH 11.1(2001):61-67.