An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy

	An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy
	Zhang, ZL; Zou, WG; Luo, CX; Li, BH; Wang, JH; Sun, LY; Qian, QJ; Liu, XY
刊名	CELL RESEARCH
	2003
卷号	13 期号:6 页码:481-489
关键词	ZD55-gene oncolytic adenovirus E1B 55-kD gene cancer Gene-ViroTherapy
通讯作者	Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Biotechnol Lab, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn
英文摘要	ONYX-015 is an attractive therapeutic adenovirus for cancer because it can selectively replicate in tumor cells and kill them. To date, clinical trials of this adenovirus have demonstrated marked safety but not potent enough when it was used alone. In this paper, we put forward a novel concept of Gene-ViroTherapy strategy and in this way, we constructed an armed therapeutic oncolytic adenovirus system, ZD55-gene, which is not only deleted of E1B55-kD gene similar to ONYX-015, but also armed with foreign antitumor gene. ZD55-gene exhibited similar cytopathic effects and replication kinetics to that of ONYX-015 in vitro. Importantly, the carried gene is expressed and the expression level can increase with the replication of virus. Consequently, a significant antitumoral efficacy was observed when ZD55-CD/5-FU was used as an example in nude mice with subcutaneous human SW620 colon cancer. Our data demonstrated that ZD55-gene, which utilizing the Gene-ViroTherapy strategy, is more efficacious than each individual component in vivo.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	SELECTIVELY-REPLICATING ADENOVIRUS ; COMPETENT ADENOVIRUS ; THERAPEUTIC VIRUSES ; GENE DELIVERY ; TUMOR-CELLS ; NECK-CANCER ; E3 REGION ; ONYX-015 ; CARCINOMA ; E1B-55K
收录类别	SCI
语种	英语
WOS记录号	WOS:000187857000007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2311]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, ZL,Zou, WG,Luo, CX,et al. An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy[J]. CELL RESEARCH,2003,13(6):481-489.
APA	Zhang, ZL.,Zou, WG.,Luo, CX.,Li, BH.,Wang, JH.,...&Liu, XY.(2003).An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy.CELL RESEARCH,13(6),481-489.
MLA	Zhang, ZL,et al."An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy".CELL RESEARCH 13.6(2003):481-489.