Synthesis of OSW-1 analogs with modified side chains and their antitumor activities

	Synthesis of OSW-1 analogs with modified side chains and their antitumor activities
	Deng, LH; Wu, H; Yu, B; Jiang, MR; Wu, JR
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2004
卷号	14 期号:11 页码:2781-2785
关键词	OSW-1 analogs side chain synthesis antitumor
通讯作者	Yu, B (reprint author), Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China.,byu@mail.sioc.ac.cn
英文摘要	Four analogs of OSW-1 (1-4) with modified side chains on the steroidal skeleton were synthesized following modification of our previous route for the total synthesis of OSW-1. Testing of the analogs against growth of tumor cells demonstrated that the 22-one function and the full length of the side chain of OSW-1 were not required for the antitumor action of OSW-1. (C) 2004 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy ; Chemistry
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
关键词[WOS]	NATURAL PRODUCT OSW-1 ; CHOLESTANE GLYCOSIDES ; ORNITHOGALUM-SAUNDERSIAE ; CYTOSTATIC ACTIVITY ; SAPONIN OSW-1 ; BULBS ; CELLS ; DISACCHARIDE ; AGLYCONE ; BEARING
收录类别	SCI
语种	英语
WOS记录号	WOS:000221561600013
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2156]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Deng, LH,Wu, H,Yu, B,et al. Synthesis of OSW-1 analogs with modified side chains and their antitumor activities[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2004,14(11):2781-2785.
APA	Deng, LH,Wu, H,Yu, B,Jiang, MR,&Wu, JR.(2004).Synthesis of OSW-1 analogs with modified side chains and their antitumor activities.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,14(11),2781-2785.
MLA	Deng, LH,et al."Synthesis of OSW-1 analogs with modified side chains and their antitumor activities".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14.11(2004):2781-2785.