Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis

	Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis
	Jin, Y; Wei, Y; Xiong, L; Yang, Y; Wu, JR
刊名	CELL RESEARCH
	2005
卷号	15 期号:5 页码:361-370
关键词	apoptosis cell cycle p53 survivin HeLa cell
通讯作者	Wu, JR (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,wujr@sibs.ac.cn
英文摘要	Recent studies indicate that cell-cycle checkpoints are tightly correlated with the regulation of apoptosis, in which p53 plays an important role. Our present works show that the expression of E6/E7 oncogenes of human papillomavirus in HeLa cells is inhibited in the presence of anti-tumor reagent tripchlorolide (TC), which results in the up-regulation of p53 in HeLa cells. Interestingly, under the same TC-treatment, the cells at the early S-phase are more susceptible to apoptosis than those at the middle S-phase although p53 protein is stabilized to the same level in both situations. Significant difference is exhibited between the two specified expression profiles. Further analysis demonstrates that anti-apoptotic gene survivin is up-regulated by p53 in the TC-treated middle-S cells, whereas it is down-regulated by p53 in the TC-treated early-S cells. Taken together, the present study indicates that the differential p53-regulated expression of survivin at different stages of the cell cycle results in different cellular outputs under the same apoptosis-inducer.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	CERVICAL-CARCINOMA CELLS ; WILD-TYPE P53 ; SPINDLE CHECKPOINT ; EPITHELIAL-CELLS ; PROTEIN-KINASES ; CANCER CELLS ; C-MYC ; TRIPTOLIDE ; ACTIVATION ; PHOSPHORYLATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000230838800005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1918]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Jin, Y,Wei, Y,Xiong, L,et al. Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis[J]. CELL RESEARCH,2005,15(5):361-370.
APA	Jin, Y,Wei, Y,Xiong, L,Yang, Y,&Wu, JR.(2005).Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis.CELL RESEARCH,15(5),361-370.
MLA	Jin, Y,et al."Differential regulation of survivin by p53 contributes to cell cycle dependent apoptosis".CELL RESEARCH 15.5(2005):361-370.