Reserpine-induced model of stress suppresses mucosal immunity

	Reserpine-induced model of stress suppresses mucosal immunity
	Bao, S; Fei, J; Shen, J; Gong, SJ; Fang, H; Husband, AJ
刊名	IMMUNOLOGY AND CELL BIOLOGY
	2006
卷号	84 期号:6 页码:537-542
关键词	humoral immunity intestine mucosa stress/depression
通讯作者	Bao, S (reprint author), Univ Sydney, Fac Med, Dept Pathol, Discipline Pathol, Sydney, NSW 2006, Australia.,bobbao@med.usyd.edu.au
英文摘要	Stress contributes significantly to the development of many diseases. In clinical studies, a strong correlation between depression and immune dysfunction has been shown. Our previous studies indicated that sympathetic innervation can regulate intestinal mucosal immunity through sympathetic synapses, but the mechanism in stress/depression-induced intestinal immune deficiency was unclear. Using a mouse model in which behavioural stress/depression is chemically induced by reserpine, it is found that there is a substantial deficiency of intestinal local humoral and particularly specific antibody response to the antigen stimulation in reserpine-treated group. No significant difference of CD4(+), CD8(+) or Mac1(+) cells between reserpine-treated and control groups was detected in the intestine. This deficiency is closely correlated with stress/depression. A possible correlation between stress, cytokine secretion and humoral immunity in vivo is postulated.
学科主题	Cell Biology ; Immunology
类目[WOS]	Cell Biology ; Immunology
关键词[WOS]	SYMPATHETIC INNERVATION ; IN-VIVO ; RESPONSES ; GAMMA ; MICE ; RAT ; INTERLEUKIN-6 ; PARAGANGLIA ; ANTIBODIES ; INDUCTION
收录类别	SCI
语种	英语
WOS记录号	WOS:000241624800006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1724]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Bao, S,Fei, J,Shen, J,et al. Reserpine-induced model of stress suppresses mucosal immunity[J]. IMMUNOLOGY AND CELL BIOLOGY,2006,84(6):537-542.
APA	Bao, S,Fei, J,Shen, J,Gong, SJ,Fang, H,&Husband, AJ.(2006).Reserpine-induced model of stress suppresses mucosal immunity.IMMUNOLOGY AND CELL BIOLOGY,84(6),537-542.
MLA	Bao, S,et al."Reserpine-induced model of stress suppresses mucosal immunity".IMMUNOLOGY AND CELL BIOLOGY 84.6(2006):537-542.