P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis

	P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis
	Chen, M; Geng, JG
刊名	ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
	2006
卷号	54 期号:2 页码:75-84
关键词	selectin cell adhesion molecule leukocytes platelets endothelial cells cancer cells inflammation thrombosis cancer growth and metastasis
通讯作者	Geng, JG (reprint author), Univ Minnesota, Sch Med, Vasc Viol Ctr, MMC 480,420 Delaware St SE, Minneapolis, MN 55455 USA.,gengx011@umn.edu
英文摘要	Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. Cross-linking of PSGL-1 by P-selectin also primes leukocytes intracellularly for cytokine and chemoattractant-induced beta(2)-integrin activation for firm adhesion of leukocytes. Furthermore, P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Here we provide a comprehensive summary of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, and the growth and metastasis of cancers.
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	ALPHA-GRANULE SECRETION ; VON-WILLEBRAND-FACTOR ; STIMULUS-INDUCED RELEASE ; HUMAN ENDOTHELIAL-CELLS ; GLYCOPROTEIN LIGAND-1 ; IN-VIVO ; CYTOPLASMIC DOMAIN ; MEMBRANE-PROTEIN ; NEUTROPHIL ADHESION ; DEFICIENT MICE
收录类别	SCI
语种	英语
WOS记录号	WOS:000237200700001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1668]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, M,Geng, JG. P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis[J]. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS,2006,54(2):75-84.
APA	Chen, M,&Geng, JG.(2006).P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis.ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS,54(2),75-84.
MLA	Chen, M,et al."P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis".ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 54.2(2006):75-84.