Reduced aggression in mice lacking GABA transporter subtype 1

	Reduced aggression in mice lacking GABA transporter subtype 1
	Liu, GX; Liu, SA; Cai, GQ; Sheng, ZJ; Cai, YQ; Jiang, J; Sun, X; Ma, SK; Wang, L; Wang, ZG
刊名	JOURNAL OF NEUROSCIENCE RESEARCH
	2007
卷号	85 期号:3 页码:649-655
关键词	GABA GABA transporter aggression gene knock out mouse
通讯作者	Fei, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Model Organism Res Ctr, Inst Biochem & Cell Biol,Lab Mol Cell Biol, 7 Bldg,319 Yue Yang Rd, Shanghai 200031, Peoples R China.,jfei@sibs.ac.cn
英文摘要	Dysregulation of the brain GABAergic system has been implicated in the pathophysiology of violence and aggression. As a key regulator of central GABAergic activity, dysfunction of the GABA transporter subtype 1 (GAT1) represents a potential mechanism mediating pathologic aggression. We provide evidence that GAT1-/- mice and GAT1+/- mice exhibit lower aggressive behavior both in home cage resident-intruder test and neutral arena resident-intruder test, compared to wild-type mice (GAT1+/+). The pharmacologic effects of the GAT1 inhibitor, tiagabine and the GABA(A) receptor antagonist, bicuculline have been assessed in GAT1+/+ mice: tiagabine inhibits attacks but bicuculline induces attacks. Compared to GAT1+/- and +/+ mice, the GAT1-/- mice displayed a normal circadian pattern of home cage activity, but more activity overall. Meanwhile, reduced testosterone concentration was found in GAT1-/- mice compared to GAT1+/+ mice but not in GAT1+/+ mice treated with tiagabine, suggesting that testosterone is not directly involved in GAT1 mediated aggressive behavior regulation. These results showed that GAT1 is an important target involved in the regulation of aggressive behavior in mice, and long-term dysfunction of GAT1 may also result in the alteration of testosterone secretion. (c) 2006 Wiley-Liss, Inc.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	BEHAVIORAL-RESPONSES ; RAT-BRAIN ; HYPOTHALAMUS ; STIMULATION ; TIAGABINE ; RAGE ; TESTOSTERONE ; LOCALIZATION ; EXPRESSION ; RECEPTORS
收录类别	SCI
语种	英语
WOS记录号	WOS:000244472000019
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1543]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, GX,Liu, SA,Cai, GQ,et al. Reduced aggression in mice lacking GABA transporter subtype 1[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2007,85(3):649-655.
APA	Liu, GX.,Liu, SA.,Cai, GQ.,Sheng, ZJ.,Cai, YQ.,...&Fei, J.(2007).Reduced aggression in mice lacking GABA transporter subtype 1.JOURNAL OF NEUROSCIENCE RESEARCH,85(3),649-655.
MLA	Liu, GX,et al."Reduced aggression in mice lacking GABA transporter subtype 1".JOURNAL OF NEUROSCIENCE RESEARCH 85.3(2007):649-655.