Molecular mechanism of abnormal aggregation of alpha-synuclein

	Molecular mechanism of abnormal aggregation of alpha-synuclein
	Hu, H; Lin, X
刊名	CHINESE SCIENCE BULLETIN
	2007
卷号	52 期号:2 页码:159-164
关键词	alpha-synuclein aggregation molecular mechanism Parkinson's disease
通讯作者	Hu, H (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn
英文摘要	The abnormal aggregation of alpha-synuclein (alpha-Syn) is thought to be closely associated with Parkinson's disease, but the pathogenesis is still unclear. In this review, we survey the latest development in the molecular mechanism of abnormal alpha-Syn aggregation, especially in the aspects of the core sequences, aggregation inhibitors, structural transformation and filament morphologies. By exploring the mechanism of alpha-Syn aggregation, we will have a better understanding of the disease pathogenesis, and develop strategies for preventing and treating this severe disease.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	ATOMIC-FORCE MICROSCOPY ; PARKINSONS-DISEASE ; BETA-SHEET ; CIRCULAR-DICHROISM ; SECONDARY STRUCTURE ; AMYLOID PROTEINS ; SOLID-STATE ; FIBRILS ; FIBRILLIZATION ; COMPONENT
收录类别	SCI
语种	英语
WOS记录号	WOS:000245638500002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1534]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Hu, H,Lin, X. Molecular mechanism of abnormal aggregation of alpha-synuclein[J]. CHINESE SCIENCE BULLETIN,2007,52(2):159-164.
APA	Hu, H,&Lin, X.(2007).Molecular mechanism of abnormal aggregation of alpha-synuclein.CHINESE SCIENCE BULLETIN,52(2),159-164.
MLA	Hu, H,et al."Molecular mechanism of abnormal aggregation of alpha-synuclein".CHINESE SCIENCE BULLETIN 52.2(2007):159-164.