HF-LANa, a human homologue of Derlin family, regulating the expression of cancer-related genes promotes NIH3T3 cell transformation

	HF-LANa, a human homologue of Derlin family, regulating the expression of cancer-related genes promotes NIH3T3 cell transformation
	Hu, YH; Ying, H; Xu, YH
刊名	CANCER LETTERS
	2007
卷号	258 期号:2 页码:171-180
关键词	hF-LANa Transformation oncogene/proto-oncogene tumor suppressor gene mouse oligo cDNA expression assay
通讯作者	Xu, YH (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,Lab Mol & Cellular Oncol, 320 YueYang Rd, Shanghai 200031, Peoples R China.,yhxu@sibs.ac.cn
英文摘要	hF-LANa, a member of Derlin family, is a putative proto-oncogene and has a direct role in oncogenic transformation. hF-LANa over-expressed NIH3T3 cells grow 20% quicker than parent cells. Especially, hF-LANa over-expression promotes anchorage-independent growth of NIH3T3 cells in soft agar and tumorigenesis in nude mice. Analysis by cDNA microarray finds 252 up-regulated genes and 354 down-regulated genes in hF-LANa over-expressed NIH3T3 cells including 19 oncogenes/proto-oncogenes and 13 tumor suppressor genes/putative tumor suppressors. These experiments show the oncogenic transformation role of hF-LANa both in vitro and in vivo, and highlight the genes that might be related to hF-LANa's oncogenic effects. (c) 2007 Published by Elsevier Ireland Ltd.
学科主题	Oncology
类目[WOS]	Oncology
关键词[WOS]	ENDOPLASMIC-RETICULUM MEMBRANE ; HEPATOCELLULAR-CARCINOMA ; MISFOLDED PROTEINS ; DEGRADATION ; GROWTH ; RB ; ER ; IDENTIFICATION ; TUMORIGENESIS ; DISLOCATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000251852600003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1517]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Hu, YH,Ying, H,Xu, YH. HF-LANa, a human homologue of Derlin family, regulating the expression of cancer-related genes promotes NIH3T3 cell transformation[J]. CANCER LETTERS,2007,258(2):171-180.
APA	Hu, YH,Ying, H,&Xu, YH.(2007).HF-LANa, a human homologue of Derlin family, regulating the expression of cancer-related genes promotes NIH3T3 cell transformation.CANCER LETTERS,258(2),171-180.
MLA	Hu, YH,et al."HF-LANa, a human homologue of Derlin family, regulating the expression of cancer-related genes promotes NIH3T3 cell transformation".CANCER LETTERS 258.2(2007):171-180.