Biological characteristics of dengue virus and potential targets for drug design

	Biological characteristics of dengue virus and potential targets for drug design
	Qi, RF; Zhang, L; Chi, CW
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2008
卷号	40 期号:2 页码:91-101
关键词	dengue virus NS3 protease polyprotein processing drug target
通讯作者	Chi, CW (reprint author), Tongji Univ, Inst Prot Res, Shanghai 200092, Peoples R China.,zwqi@sibs.ac.cn
英文摘要	Dengue infection is a major cause of morbidity in tropical and subtropical regions, bringing nearly 40% of the world population at risk and causing more than 20,000 deaths per year. But there is neither a vaccine for dengue disease nor antiviral drugs to treat the infection. In recent years, dengue infection has been particularly prevalent in India, Southeast Asia, Brazil, and Guangdong Province, China. In this article, we present a brief summary of the biological characteristics of dengue virus and associated flaviviruses, and outline the progress on studies of vaccines and drugs based on potential targets of the dengue virus.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	BORNE ENCEPHALITIS-VIRUS ; DEPENDENT RNA-POLYMERASE ; YELLOW-FEVER VIRUS ; WEST-NILE-VIRUS ; STIMULATED NUCLEOSIDE TRIPHOSPHATASE ; FLAVIVIRUS ENVELOPE GLYCOPROTEIN ; NONSTRUCTURAL PROTEIN NS3 ; RETRACTED ARTICLE. SEE ; IN-VITRO ; MONOCLONAL-ANTIBODIES
收录类别	SCI
语种	英语
WOS记录号	WOS:000253501900001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1335]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Qi, RF,Zhang, L,Chi, CW. Biological characteristics of dengue virus and potential targets for drug design[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2008,40(2):91-101.
APA	Qi, RF,Zhang, L,&Chi, CW.(2008).Biological characteristics of dengue virus and potential targets for drug design.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,40(2),91-101.
MLA	Qi, RF,et al."Biological characteristics of dengue virus and potential targets for drug design".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 40.2(2008):91-101.