Mechanisms of microRNA-mediated gene regulation

	Mechanisms of microRNA-mediated gene regulation
	Zhao, S; Liu, MF
刊名	SCIENCE IN CHINA SERIES C-LIFE SCIENCES
	2009
卷号	52 期号:12 页码:1111-1116
关键词	miRNA repression activation de-repression processing bodies stress granules
通讯作者	Liu, MF (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,mfliu@sibs.ac.cn
英文摘要	microRNAs (miRNAs) are identified as a class of non-protein regulators and a new source for broad control of gene expression in eukaryotes. The past years have witnessed substantial progress in understanding miRNA functions and mechanisms, although a few controversies remain. Various hypotheses and models have been suggested for the mechanisms of miRNA repression, including translational inhibition at the level of initiation or elongation, rapid degradation of the nascent peptide, mRNA degradation, and mRNA sequestration into P bodies (processing bodies) and SGs (stress granules) for degradation or/and storage. Recently, some noncanonical miRNA regulation, such as miRNA activation and de-repression of miRNA inhibition, have been uncovered. This review discusses some recent advances about how miRNAs regulate their targets and various modes of miRNA function.
学科主题	Life Sciences & Biomedicine - Other Topics
类目[WOS]	Biology
关键词[WOS]	MESSENGER-RNA ; TRANSLATION INITIATION ; POSTTRANSCRIPTIONAL REGULATION ; DEPENDENT LOCALIZATION ; ARGONAUTE PROTEINS ; LET-7 MICRORNA ; HUMAN-CELLS ; DEADENYLATION ; INHIBITION ; REPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000272869700002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1269]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhao, S,Liu, MF. Mechanisms of microRNA-mediated gene regulation[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2009,52(12):1111-1116.
APA	Zhao, S,&Liu, MF.(2009).Mechanisms of microRNA-mediated gene regulation.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,52(12),1111-1116.
MLA	Zhao, S,et al."Mechanisms of microRNA-mediated gene regulation".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 52.12(2009):1111-1116.