In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta(3),2-hydroxybakuchiol isolated from Psoralea corylifolia (L.)

	In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta(3),2-hydroxybakuchiol isolated from Psoralea corylifolia (L.)
	Zhao, G; Zheng, XW; Qin, GW; Gai, Y; Jiang, ZH; Guo, LH
刊名	CELLULAR AND MOLECULAR LIFE SCIENCES
	2009
卷号	66 期号:9 页码:1617-1629
关键词	Delta(3) scale-up extraction dopamine transporter reuptake inhibitor Parkinson's disease 2-hydroxybakuchiol
通讯作者	Guo, LH (reprint author), Cell Star Biotechnol Co Ltd, Bldg 6,Lane 898 Halei Rd, Shanghai 201203, Peoples R China.,lhguo@sibs.ac.cn
英文摘要	Cocktail recipes containing Psoralea corylifolia seeds (PCS) are used to empirically treat Parkinson disease. A PCS isolate Delta(3),2-hydroxybakuchiol (BU) can inhibit dopamine uptake in dopamine transporter (DAT) transfected Chinese hamster ovary (CHO) cells, and dopamine reuptake blockade may provide an alternative approach for ameliorating parkinsonism. Here, we assessed the potential dopaminergic neuroprotective, and antiparkinsonian-like activity of BU. BU sample size was increased by using a scale-up extraction paradigm. Pharmacologically, BU significantly protected SK-N-SH cells from 1-methyl-4-phenylpyridinium (MPP+) insult, produced striking inhibitory actions on dopamine/norepinephrine uptake and WIN35,428 binding in synaptosomes on in vivo administration, and significantly preventing poor performance on rotarod and dopaminergic loss in substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice. BU acts by protecting dopaminergic neurons from MPP+ injury and preventing against MPTP-induced behavioral and histological lesions in the Parkinson's disease (PD) model, possibly by inhibiting monoamine transporters. These findings suggest that BU could be meaningful in PD treatment.
学科主题	Biochemistry & Molecular Biology; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]	FORCED SWIMMING TEST ; PARKINSONS-DISEASE ; NORADRENALINE TRANSPORTER ; REUPTAKE INHIBITION ; TOTAL FUROCOUMARINS ; TETRAZOLIUM SALT ; SUBSTANTIA-NIGRA ; MPTP ; SEEDS ; MICE
收录类别	SCI
语种	英语
WOS记录号	WOS:000267484700011
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1238]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhao, G,Zheng, XW,Qin, GW,et al. In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta(3),2-hydroxybakuchiol isolated from Psoralea corylifolia (L.)[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2009,66(9):1617-1629.
APA	Zhao, G,Zheng, XW,Qin, GW,Gai, Y,Jiang, ZH,&Guo, LH.(2009).In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta(3),2-hydroxybakuchiol isolated from Psoralea corylifolia (L.).CELLULAR AND MOLECULAR LIFE SCIENCES,66(9),1617-1629.
MLA	Zhao, G,et al."In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta(3),2-hydroxybakuchiol isolated from Psoralea corylifolia (L.)".CELLULAR AND MOLECULAR LIFE SCIENCES 66.9(2009):1617-1629.