Novel conopeptides in a form of disulfide-crosslinked dimer

	Novel conopeptides in a form of disulfide-crosslinked dimer
	Wu, XC; Zhou, M; Peng, C; Shao, XX; Guo, ZY; Chi, CW
刊名	PEPTIDES
	2010
卷号	31 期号:6 页码:1001-1006
关键词	Conopeptide Dimer Disulfide M-superfamily
通讯作者	Guo, ZY (reprint author), Tongji Univ, Inst Prot Res, 1239 Siping Rd, Shanghai 200092, Peoples R China.,zhan-yun.guo@tongji.edu.cn ; zwqi@sibs.ac.cn
英文摘要	In our present work, seven conotoxins and conopeptides were cloned from four cone snail species based on the M-superfamily signal peptides. Among them, two conopeptides, Vt3.1 and Vt3.2, showed unusual sequence characteristics. Both of them contained two cysteines that are separated by just one non-cysteine residue. In vitro, the chemically synthesized Vt3.1 formed dimers with different intermolecular disulfide linkages. Only the dimer with crossed disulfides showed bioactivity when injected into the intraventricular region of mice brains. Therefore, Vt3.1 and Vt3.2 represent a new group of conopeptides that form disulfide-crosslinked dimers in vitro and probably in vivo. (C) 2010 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Pharmacology & Pharmacy
类目[WOS]	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]	M-SUPERFAMILY CONOTOXINS ; CDNA CLONING ; CONUS VENOMS ; PEPTIDES ; PRECURSORS
收录类别	SCI
语种	英语
WOS记录号	WOS:000283939000003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1018]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wu, XC,Zhou, M,Peng, C,et al. Novel conopeptides in a form of disulfide-crosslinked dimer[J]. PEPTIDES,2010,31(6):1001-1006.
APA	Wu, XC,Zhou, M,Peng, C,Shao, XX,Guo, ZY,&Chi, CW.(2010).Novel conopeptides in a form of disulfide-crosslinked dimer.PEPTIDES,31(6),1001-1006.
MLA	Wu, XC,et al."Novel conopeptides in a form of disulfide-crosslinked dimer".PEPTIDES 31.6(2010):1001-1006.